Association of hypertensive disorders complicating pregnancy with small for gestational age infants
MI Shengnan, ZHU Yibing, YAN Huina, HAO Yongxiu, LIU Yingying, LI Nan, YE Rongwei
Institute of Reproductive and Child Health, Peking University/National Health Commission Key Laboratory of Reproductive Health;
Department of Epidemiology and Biostatistics, School of Public Health, Beijing 100191, China
Abstract：Objective To investigate the incidence of hypertensive disorders complicating pregnancy (HDCP) and small for gestational age babies(SGA) in 5 counties of Hebei province, association of severity, onset time and subtype of HDCP with SGA was also explored.Methods The data was from "Pregnancy Nutrition Project" which was a part of China-US Collaborative Project on Birth Defects and Disabilities Prevention conducted in 2006-2009 in 5 counties of Hebei. Stratified analysis was performed on preterm and term birth and HDCP was grouped according to subtype, severity and time of onset. The Chi-square test was used to compare the incidence of SGA in each group and estimate relative risk (RR). Unconditional logistic regression was used for multivariate analysis to estimate odds ratio (OR) and 95% confidence intervals (95%CI).Results A total of 1 207 cases with HDCP among 17 262 pregnant women, the incidence was 7.0%; 1 238 SGA were found among offspring with the incidence was 7.2%. The RR of SGA in HDCP group was 1.17(0.94, 1.45), the RR of SGA in premature delivery pregnant women was 7.94(3.14, 20.03) stratified by preterm and term birth. There was no significant difference between the incidence of SGA in HDCP group and non-HDCP group. The OR of SGA in the HDCP group, the pregnancy induced hypertension group, the severe HDCP group and the early-onset HDCP group were 1.31(1.06, 1.63), 1.29(1.03, 1.62), 3.63(2.00, 6.58) and 1.86(1.13, 3.07), respectively, after adjustment by maternal age, BMI, occupation, ethnicity, education, gravidity, pregnancy test times, preterm, smoking status and pill-taking or not.Conclusion HDCP is a risk factor for SGA. More severe and earlier the onset of HDCP would increase the risk of SGA, but chronic hypertension is not associated with SGA; HDCP was related with SGA in preterm birth, but not in term births. Preventing HDCP, providing reasonable health guidance, and strengthening the perinatal monitoring and intervention would be helpful to reduce the occurrence of SGA .
米胜男,朱怡冰,闫会娜,郝永秀,刘莹颖,李楠,叶荣伟. 妊娠期高血压疾病与小于胎龄儿的关联研究[J]. 中国生育健康杂志, 2018, 29(5): 407-410.
MI Shengnan, ZHU Yibing, YAN Huina, HAO Yongxiu, LIU Yingying, LI Nan, YE Rongwei. Association of hypertensive disorders complicating pregnancy with small for gestational age infants. Chinese Journal of Reproductive Health, 2018, 29(5): 407-410.
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