NLR、MLR在卵巢肿瘤中的应用进展

摘要
图/表
参考文献
相关文章 (4)

全文: PDF (668 KB) HTML (27 KB)
输出: BibTeX | EndNote (RIS)

摘要随着科技的日新月异和社会的不断发展,卵巢肿瘤已经引起妇女的重视,而且随着研究的不断深入,发现肿瘤相关炎症反应可能与卵巢肿瘤的发生及发展具有相关性,并且其对卵巢肿瘤的早期诊断、病情监测及预测不良预后都有一定的临床意义。本文对中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)与卵巢肿瘤关系进行讨论,期待可以为卵巢肿瘤的诊断、鉴别诊断及预后预测提供一些新的思路。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	李美玲
	张广美

关键词 ：中性粒细胞与淋巴细胞比值, 单核细胞与淋巴细胞比值, 卵巢肿瘤

收稿日期: 2018-09-21

引用本文:

李美玲, 张广美. NLR、MLR在卵巢肿瘤中的应用进展[J]. 中国生育健康杂志, 2019, 30(6): 597-600.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2019/V30/I6/597

1 David H.Rudolf Virchow and modern aspects of tumor pathology.Pathol Res Pract,1988,183:356-364.
2 Lee J,Kim DM,Lee A.Prognostic Role and Clinical Association of Tumor-Infiltrating Lymphocyte,Programmed Death Ligand-1 Expression with Neutrophil-Lymphocyte Ratio in Locally Advanced Triple-Negative Breast Cancer.Cancer Res Treat,2018,31:31.
3 Yilmaz B,Senqul E,Gul A,et al.Neutrophil-Lymphocyte Ratio as a Prognostic Factor in Laryngeal Carcinoma.Indian J of Otolaryngol Head Neck Surg,2018,70:175-179.
4 Lorente D,Mateo J,Templeton AJ,et al.Baseline neutrophil-lymphocyte ratio(NLR) is associated with survival and response to treatment with second-line chemotherapy for advanced prostate cancer independent of baseline steroid use.Ann Oncol,2015,26:750-755.
5 Cruz RM,Del Puerto-Nevado L,Zheng B,et al.Prognostic significance of neutrophil-to lymphocyte ratio and platelet-to lymphocyte ratio in older patients with metastatic colorectal cancer.Geriatr Oncol,2018,13:1879-4068.
6 Eo WK,Kim KH,Park EJ,et al.Diagnostic accuracy of inflammatory markers for distinguishing malignant and benign ovarian masses.J Cancer,2018,9:1165-1172.
7 Magdy M,Hussein T,Ezzat T,et al.Pre-treatment Peripheral Neutrophil-Lymphocyte Ratio as a Prognostic Marker in Gastric Cancer.J Gastrointest Cancer,2018,4:1-6.
8 Wenqner AM,Pitchford SC,Furze SC,et al.The coordinated action of G-CSF and ELR+CXC chemokines in neutrophil mobilization during acute inflammation.Blood,2008,111:42-49.
9 Kohler A,De FK,Hasenberg M,et al.G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.Blood,2011,117:4349-4357.
10 Kim HK,Wimlliams CK,Gulino AV,et al.G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells.Blood,2016,108:812-820.
11 Coffelt SB,Wellenstein MD,Visser KE.Neutrophils in cancer:neutral no more.Nat Rev Cancer,2016,16:431-446.
12 Jiao J,Draqomir AC,Kocabayoqlu P,et al.Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophil.J Immunol,2014,192:3374-82.
13 Casbon AJ,Reynaud D,Park C,et al.Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.Proc Natl Acad Sci USA,2015,112:566-575.
14 Coffelt SB.IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis.Nature,2015,522:345-348.
15 Acharyya S,Oskarsson T,Vanharanta S,et al.A CXCL1 paracrine network links cancer chemoresistance and metastasis.Cell,2016,150:165-178.
16 Carmi Y,Rinott G,Dotan S,et al.Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis.J Immunol,2011,186:3462-3471.
17 Benevides L,da Fonseca DM,Donate PB,et al.IL-17 promotes mammary tumor progression by changing the behavior of tumor cells and eliciting tumorigenic neutrophils recruitment.Cancer Res,2015,75:3788-3799.
18 Li Z,Pang Y,Gara SK,et al.Gr-1+CD11b+ cells are responsible for tumor promoting effect of TGF-β in breast cancer progression.Int J Cancer,2012,131:2584-2595.
19 Silva RNF,Dallarmi LB,Araujo AKC,et al.Immunohistochemical analysis of neutrophils,interleukin-17,matrix metalloproteinase-9,and neoformed vessels in oral squamous cell carcinoma.J Oral Pathol Med,2018,47:856-863.
20 Gabrilovich DL,Ostrand RS,Bronte V.Coordinated regulation of myeloid cells by tumours.Nat Rev Immunol,2012,12:253-68.
21 吴鹏.JQ1抑制肿瘤相关巨噬细胞Fra1基因表达对小鼠乳腺癌生长及转移的影响研究.北京:北京协和医学院,2016.
22 Zhu Q,Wu X,Wang X.Differential distribution of tumor-associated macrophages and Treg/Th17 cells in the progression of malignant and benign epithelial ovarian tumors.Oncol Lett,2017,13:159-166.
23 Yin M,Li X,Tan S,et al.Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer.J Clin Invest,2016,126:4157-4173.
24 Li,Wang J,Chen R,et al.The prognostic value of tumor-infiltrating T lymphocytes in ovarian cancer.Oncotarget,2017,8:15621-15631.
25 Ruka W,Rutkowski P,Kaminska J,et al.Alterations of routine blood tests in adult patients with soft tissue sarcomas:relationships to cytokine serum levels and prognostic significance.Ann Oncol,2001,12:1423-1432.
26 Ranjbar R,Nejatollahi F,Nedaei AS,et al.Expression of Vascular Endothelial Growth Factor (VEGF) and Epidermal Growth Factor Receptor (EGFR) in Patients With Serous Ovarian Carcinoma and Their Clinical Significance.Iran J Cancer Prev,2015,8:3428.
27 Figueira RL,Gonçalves FL,Prado AR,et al.Ventilation-induced changes correlate to pulmonary vascular response and VEGF,VEGFR-1/2,and eNOS expression in the rat model of postnatal hypoxia.Braz J Med Biol Res,2018,51:7169.
28 侯嘉杰,孙倍成.STAT3:慢性炎症介导肿瘤发生和进展的关键节点.生物化学与生物物理进展,2016,41:69-78.
29 葛婷雯,崔久嵬.肿瘤与肿瘤炎症微环境相互促进机制研究进展.临床检验杂志,2017,35 :11.
30 Guerra C,Schuhmacher AJ,Canamero M,et al.Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.Cancer Cell,2007,11:291-302.
31 王芳,张阳,李大兵.外周血NLR 在无症状卵巢上皮癌早期诊断中的价值.海南医学,2017,27:1283-1284.
32 Prodromidou A,Andreakos P,Kazakos.The diagnostic efficacy of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in ovarian cancer.Inflamm Res,2017,66:467-475.
33 张彦骅.NLR与PLR联合CA-125对上皮性卵巢癌早期诊断及预后评估的研究.兰州:兰州大学,2015.
34 Bakacak M,Serin S,Ercan O,et al.Utility of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios to distinguish malignant from benign ovarian masses.J Turk Ger Gynecol Assoc,2016,17:21-25.
35 徐金良,杜丹丹,翟志敏,郭进京.卵巢良恶性肿瘤患者血液NLR,LMR,RDW,PLR四项参数的变化及其临床意义.现代检验医学杂志,2018,33:16-18.
36 Eo WK,Kim KH,Park EJ,et al.Diagnostic accuracy of inflammatory markers for distinguishing malignant and benign ovarian masses.J Cancer,2018,9:1165-1172.
37 Yildiz Y,Kucukzeybek Y,Alacacioglu A.Prognostic value of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with epithelial ovarian cancer.Eur J Gynaecol Oncol.2017,38:444-448.
38 唐英,李均,徐凡,等.单核细胞与淋巴细胞比值及其与上皮性卵巢癌患者预后的关系.中华妇幼临床医学杂志(电子版),2017,13:532-538.
39 刘楠,罗婉君,卢敏贞,等.中性粒细胞淋巴细胞比率对于预测卵巢癌患者预后的Meta分析.实用医学杂志,2017,33:2589-2592.
40 Kim YJ,Lee I,Chung YS,et al.Pretreatment neutrophil-to-lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancer.Obstet Gynecol Sci,2018,61:227-234.
41 Xiang J,Zhou L,Li X,et al.Preoperative Monocyte-to-Lymphocyte Ratio in Peripheral Blood Predicts Stages,Metastasis,and Histological Grades in Patients with Ovarian Cancer.Transl Oncol,2017,10:33-39.
42 Komura N,Mabuchi S,Yokoi E,et al.Comparison of clinical utility between neutrophil count and neutrophil-lymphocyte ratio in patients with ovarian cancer:a single instititional experience and a literature review.Int J Clin Oncol,2018,23:104-113.