胎盘胆汁酸转运体及核受体与妊娠期肝内胆汁淤积症的研究进展

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摘要妊娠期肝内胆汁淤积症病因及发病机制尚不明确,但最终都会导致胆汁酸淤积,对胎儿产生直接或间接的毒害作用。国内外研究已经证实肝内胆汁淤积与肝脏中胆汁酸核受体、转运体相关。近年来不断发现了胆汁酸核受体、转运体在妊娠期肝内胆汁淤积症胎盘中的表达,并且推测它们在胎盘内胆汁酸的转运中发挥着关键作用。本文对胎盘胆汁酸转运体及核受体与妊娠期肝内胆汁淤积症的研究进展进行综述。

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	张建华
	李秀华

关键词 ：妊娠期肝内胆汁淤积症, 胎盘, 胆汁酸转运体, 核受体

收稿日期: 2019-01-14

通讯作者: 张建华(596174349@qq.com)

引用本文:

张建华, 李秀华. 胎盘胆汁酸转运体及核受体与妊娠期肝内胆汁淤积症的研究进展[J]. 中国生育健康杂志, 2020, 31(1): 87-89.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2020/V31/I1/87

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