Current Issue http://cjrh.bjmu.edu.cn EN-US http://cjrh.bjmu.edu.cn/EN/current.shtml http://cjrh.bjmu.edu.cn 5 Objective To understand the prevalence of suspected development delay of left-behind children under 3 years old in rural areas and the impact of home environment. Methods Five national poverty-stricken counties were selected to conduct the cross-sectional study in 2018. The modified Infant-Toddler Home Observation for Measurement of the Environment inventory (IT-HOME) was used to assess the home environment of left-behind family. Ages and Stages Questionnaires-Chinese, Third Edition (ASQ-3) were used to detect the suspected development delay of left-behind children. The chi-square test was used to compare the differences in the rates of suspected development delay among left-behind children with different characteristics, and multivariate logistic regression was applied to analyze the effects of home environment on the early development of rural left-behind children aged 0-3 years. Results A total of 878 pairs of left-behind children under the age of 3 and their caregivers were included. The overall suspected development delay rate for left-behind children aged 0-3 years was 31.8%. After controlling for children鈥瞫 gender, age, low birth weight, left-behind type and caregivers鈥� gender, age, ethnicity, education level, depression and the number of vehicles and appliances owned by the family, lack of a stimulating home environment was a risk factor for the communication, gross motor, fine motor, problem solving, and personal-social competence zones, as well as for overall suspected developmental delay, with ORs of 2.53 (95% CI: 1.51-4.24), 2.00 (95% CI: 1.12-3.57), 2.17 (95% CI: 1.31-3.61), 3.94 (95% CI: 2.42-6.42), 2.52 (95% CI: 1.47 -4.32), and 2.97 (95% CI: 1.95-4.51), respectively. Conclusion The early development status of left-behind children aged 0-3 years in the survey areas is not optimistic, and the lack of a stimulating home environment increases the risk of suspected early development delays in left-behind children.]]> Objective To analyze and forecast the incidence, prevalence and years lived with disability of depressive disorders in child-bearing women in China and provide evidence for women鈥瞫 health care in the future. Methods Based on the data of Global Burden of Disease Study 2019, the differences in the distribution of depressive disorders in Chinese women of child-bearing age (15-49 years) from 1990 to 2015 were analyzed, and the severity of depressive disorders in 2025 and 2030 were forecasted with GM (1, 1). Results The influences of dysthymia were relatively increasing in recent years in women of child-bearing age in China. The loss of health due to depressive disorders in child-bearing women might decrease in 2025, and the incidence and prevalence of depressive disorders in women aged 40~49 year might be higher than the average level of women of the child-bearing age. Conclusion The health services on depressive disorders in child-bearing women should be designed according to the age and categories of diseases, and more attention should be paid to the mental health care in perimenopausal women and the prevention and cure of dysthymia.]]> Objective To analyze the association between dietary garlic intake and risk of preterm birth. Methods A birth cohort study was conducted in 2010-2012 at Gansu Provincial Maternity & Child Care Hospital in Lanzhou, China. A total of 9,710 pregnant women were enrolled. The general demography characteristics, garlic intake in the perinatal period and the information of fetal delivery were investigated. A multivariate logistic regression models was used to analyze the relationship between dietary garlic intake and preterm birth. Results Raw garlic intake reduced the risk of preterm birth with a dose-response relationship (overall:OR=0.81, 95%CI:0.69-0.96; before pregnancy:OR=0.81, 95%CI:0.68-0.95; 锛�2 times/week:OR=0.81, 95%CI:0.69-0.97, 鈮�2 times/week:OR=0.79, 95%CI:0.64-0.97; P_trend=0.03; during pregnancy:OR=0.82, 95%CI:0.70-0.96; 锛�2 times/week:OR=0.83, 95%CI:0.71-0.98, 鈮�2 times/week:OR=0.79, 95%CI:0.65-0.97; P_trend=0.03).Especially there was a significant negative correlation with spontaneous preterm without premature rupture of membranes (overall:OR=0.67,95%CI:053-0.85;before pregnancy:OR=0.69, 95%CI:0.55-0.88; during pregnancy:OR=0.68, 95%CI:0.55-0.85). However, there was no significant association with iatrogenic preterm birth and premature rupture of membranes. Conclusion Dietary raw garlic intake can reduce the risk of preterm birth with dose-response relationship, especially spontaneous preterm without premature rupture of membranes.]]> Objective To detect the expression levels of serum histone deacetylase 4 (HDAC4) and histone deacetylase 6 (HDAC6) in patients with preeclampsia, and analyze the correlation between the two and the severity of the disease. Methods Eighty preeclampsia patients (study group) hospitalized in Northwest Women and Children鈥瞫 Hospital from January 2020 to June 2021 were selected, the patients were grouped into mild group (n=48) and severe group (n=32) according to the severity of their illness, in addition, 80 healthy pregnant women who gave birth in hospital during the same period were regarded as the control group. The general data of the study group and the control group were compared; Pearson correlation analysis was applied to analyze the correlation between serum HDAC4 level, HDAC6 level and the severity of preeclampsia, and the correlation between serum HDAC4 level and serum HDAC6 level; multivariate Logistic regression analysis was applied to analyze the factors influencing the occurrence of preeclampsia in pregnant women; the evaluation value of serum HDAC4 and HDAC6 levels on the occurrence of preeclampsia was analyzed by receiver operating characteristic (ROC) curve. Results Systolic blood pressure, diastolic blood pressure, 24h urine protein content, total cholesterol, triglyceride, HDAC4, and HDAC6 in preeclampsia patients were obviously higher than those in the control group (P<0.05); the expression levels of HDAC4 and HDAC6 in severe group were obviously higher than those in mild group (P<0.05). Correlation analysis showed that serum HDAC4 and HDAC6 were obviously positively correlated with the severity of the disease (r=0.536, 0.614, P<0.001); there was a obvious positive correlation between serum HDAC4 level and HDAC6 level in patients with preeclampsia (r=0.412, P<0.001). Multivariate Logistic regression analysis showed that serum HDAC4, HDAC6, systolic blood pressure, diastolic blood pressure, 24h urine protein content, total cholesterol, and triglyceride, were the influencing factors of preeclampsia (P<0.05). The AUC of combined prediction of serum HDAC4 and HDAC6 for the occurrence of preeclampsia was 0.886, the sensitivity was 87.50%, and the specificity was 78.75%, which was superior to their respective independent prediction (Z_{combined detection-HDAC4}=2.564, Z_{combined detection-HDAC6}=4.083, P<0.05). Conclusion The serum HDAC4 and HDAC6 levels in patients with preeclampsia are closely related to the occurrence and severity of the disease, and the combination of the two has a good reference value for pregnant women with preeclampsia.]]> Objective This study aims to determine the prevalence of intimate partner violence (IPV) against pregnant women and the risk of adverse birth outcomes (ABO) in pregnant women in Wuhan, China. Methods The survey was conducted among 806 pregnant women at Tongji Hospital, Qiaokou District Maternity and child care hospital and Dongxihu District People鈥瞫 Hospital in Wuhan from April 2013 to March 2014. Face-to-face standardized interviews were performed prior to woman鈥瞫 antenatal care. IPV and depressive symptoms were assessed through the Abuse Assessment Screen (AAS) and the Center for Epidemiologic Studies-Depression scale (CES-D). Birth outcomes were collected after delivery. Chi-square test was applied to compare the differences of prevalence rate of various ABO between IPV and non-IPV groups, Path analysis was used to determine the risk for ABO in women experienced IPV during pregnancy. Results 18.3% of 797 participants reported experiencing IPV during pregnancy. Husband鈥瞫 personality, pregnancy complications, depression and IPV had direct effects on ABO, the influence coefficient were 0.107, 0.084, 0.095, and 0.099, respectively. Conclusion The findings revealed IPV and depression in the antenatal significantly predicted adverse birth outcomes, and assist prenatal care providers in prioritizing and screening for IPV and depression during pregnancy that are associated with ABO.]]> Objective To explore the influence of fetal heart monitoring pattern, delivery mode and perinatal prognosis in women with excessive umbilical cord torsion. Methods A retrospective case-control study was used in this study. The observation group was used to select a total of 122 women with a single fetus during delivery in a third class Hospital Obstetrics Department from January 2012 to December 2021 with excessive umbilical cord torsion. In the same period, 136 of the puerperae without excessive torsion of the umbilical cord were selected as the control group. The general condition, mode of delivery, perinatal outcomes, and the influences of fetal heart monitoring characteristics with different umbilical coiling index on fetal and neonatal outcomes were retrospectively analyzed between two groups. Results Compared with the control group, there was statistically significant differences in mean gestational age in the observation group (P<0.05). Also statistically significant differences in delivery mode (cesarean section or natural delivery), newborn birth weight, body length, umbilical cord length and fetal distress incidence rate (P<0.05). The type 鈪� and type 鈪� fetal heart monitoring in the observation group were significantly higher than that in the control group (P<0.05). Compared with the UCL-H and UCL-L, there were statistical significance in fetal distress, type 鈪� monitoring and type 鈪� monitoring (P<0.05) Conclusion Excessive torsion of umbilical cord have certain risk factors during pregnancy, which increase the chance of cesarean section and vaginal midwifery, and increase the incidence of fetal distress. In fetal heart monitoring, the patterns of type 鈪� and tpye 鈪� are significantly increased.]]> Objective To explore and analyze the differences in clinical features, outcomes and perinatal outcomes between delayed and timely treatment of pregnant women with tuberculosis, so as to provide empirical ideas for improving the prognosis of pregnant women with tuberculosis. Methods The medical records of pregnant women with tuberculosis admitted to the Tuberculosis Institute of the Eighth Medical Center of the PLA General Hospital from January 2017 to January 2022 were retrospectively analyzed. They were divided into the delayed treatment group and the timely treatment group. The clinical symptoms, tuberculosis outcomes and perinatal outcomes of the two groups were analyzed. Results In the delayed treatment group,7 patients (16.2%)with consciousness disorder were significantly more than 1 patient (5.5%) in the timely treatment group, the difference was statistically significant (P<0.05),but there was no statistically significant difference in the symptoms of headache, chest tightness and choking, cough and sputum and weight loss(P>0.05).In the delayed and timely treatment groups, 38 cases (82.6%) and 5 cases(27.7%) of patients with hematogenous disseminated tuberculosis/tuberculous meningitis,27 cases (58.6%) and 3 cases (16.6%) of patients with severe disease (neurological sequelae, coma),3 cases (6.5%) and 0 cases (0.0%) of patients died,and 6 cases (13) of patients with stable disease. 0%) and 10 cases (55.5%), there were statistical differences in the above indexes between the two groups (P<0.05). In perinatal outcomes, there were no significant differences in age, pre-pregnancy weight, method of termination of pregnancy, tuberculosis type, neonatal weight and live birth rate between the delayed and timely treatment groups (P>0.05).The weeks of diagnosis(22.2卤6.5 vs 15.4卤7.3) and termination of pregnancy(28.6卤9.3 vs 23.7卤14.6)in the delayed treatment group were larger than those in the timely treatment group,the difference was statistically significant (P<0.05). Conclusion Pregnancy with tuberculosis is prone to delay diagnosis and treatment; It is necessary to strengthen the education and awareness of pregnant women with tuberculosis and improve doctors鈥� awareness of pregnancy complicated with tuberculosis.Early treatment, diagnosis and treatment are helpful to improve the prognosis and perinatal outcome of pregnant women with tuberculosis.]]> Objective To investigate the correlation between sperm DNA fragmentation index(DFI), serum 25-hydroxy-vitamin D[25(OH)VD] and semen routine parameters in male infertility patients. Methods The examination data of 627 male infertility patients in the Reproductive Medicine Center of the First Affiliated Hospital of Air Force Military Medical University from November 2021 to July 2022 were retrospectively analyzed. The routine parameters of semen were analyzed by computer assisted sperm analysis system, the percentage of sperm with normal morphology was detected by manual method, the sperm DFI was analyzed by flow cytometry, and the total amount of 25(OH)VD in serum was detected by liquid chromatography-tandem mass spectrometry detection system. SPSS 25.0 software was used to analyze the correlation between sperm DFI and total sperm count, sperm concentration, percentage of forward motile sperm (PR), total sperm motility and percentage of normal morphology sperm, as well as the correlation between total amount of serum 25(OH)VD and total sperm count, concentration, PR, total sperm motility, percentage of normal morphology sperm and sperm DFI. Results Sperm DFI was negatively correlated with total sperm count and concentration (r=-0.082, -0.094, P<0.05), but r<0.1, with limited clinical value. Sperm DFI was negatively correlated with PR, total sperm motility and percentage of normal morphology sperm (r =-0.519, -0.534, -0.327, P<0.001). Serum 25(OH)VD was not correlated with total sperm count, concentration, PR and total sperm motility (r =-0.009, -0.020, 0.059, 0.054, P>0.05), but was positively correlated with the percentage of normal morphology sperm (r =0.147, P<0.001), and was negatively correlated with sperm DFI (r =-0.294, P<0.001). Conclusion Sperm DFI was negatively correlated with the PR, total sperm motility and percentage of normal morphology sperm, which could reflect sperm quality to a certain extent. Sperm DFI detection and semen routine parameters could complement each other, providing effective information for a comprehensive and objective assessment of male fertility. The total amount of serum 25(OH)VD was positively correlated with the percentage of normal morphology sperm and negatively correlated with sperm DFI, which could be used as a reference index to evaluate male fertility.]]>