胎盘特异蛋白PLAC1的特性及研究进展

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摘要胎盘特异性基因PLAC1(Placenta-specific 1 gene)是癌-睾丸(Cancer- testis antigen,CT)抗原的一种,命名CT92,特异表达于胎盘、睾丸和各种恶性肿瘤中。有6个外显子和2个启动子区域,在正常组织和肿瘤细胞中的表达通过特定的启动子驱动实现。资料显示,PLAC1可作为预测先兆子痫、先兆流产等妊娠期疾病的潜在生物标志物。研究表明PLAC1有促进肿瘤的生长和浸润等功能的潜力。它可以引发特异性免疫反应,可能影响一些癌症患者的生存及愈后。这表明它可提供一种治疗某些癌症的治疗靶标。

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	王丹
	蒋环玲
	杨晓新

关键词 ：胎盘特异性基因, 先兆子痫, 免疫原性, 肿瘤免疫治疗, 靶点

收稿日期: 2017-09-20

通讯作者: 蒋环玲(1368968500@qq.com)

引用本文:

王丹, 蒋环玲, 杨晓新. 胎盘特异蛋白PLAC1的特性及研究进展[J]. 中国生育健康杂志, 2018, 29(3): 282-285.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2018/V29/I3/282

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