肥胖对男性精液质量影响与血清TNF-α及IL-6相关性

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摘要目的探讨血清中肿瘤坏死因子α(TNF-α)及白细胞介素6(IL-6)水平的改变与肥胖的相关性及其对精液常规参数的影响。方法选择2015年1月—2015年5月于山西省妇幼保健院生殖医学中心就诊的男性患者324例为研究对象,将324例研究对象分为低体质量组、正常组、超重组及肥胖组,对各组患者行精液常规参数、精子形态、精浆锌含量、精子顶体酶活性及血清TNF-α及IL-6水平检测。同时就血清TNF-α及IL-6水平与精液常规参数之间进行相关性分析。结果低体质量组、超重组及肥胖组与正常组相比,前向运动精子百分率均显著下降,差异有统计学意义。肥胖组与正常组相比,头部缺陷精子显著增多,差异有统计学意义。而低体质量组及超重组与正常组相比精子形态差异无统计学意义。肥胖组与正常体质量组相比,精浆锌含量及精子顶体酶活性显著降低,差异有统计学意义。低体质量组及超重组与正常体质量组相比差异无统计学意义。超重与肥胖组患者血清中TNF-α及IL-6含量与正常体质量组相比均显著升高,差异有统计学意义。低体质量组与正常体组相比,血清中TNF-α及IL-6含量均差异无统计学意义。血清TNF-α及IL-6水平与男性精液密度及前向运动精子间存在相关性,而血清TNF-α及IL-6水平与患者精液量间未见相关性。结论男性肥胖患者体内不仅TNF-α及IL-6水平升高,而且与男性精液密度及前向运动精子率下降存在一定的相关性。

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	武学清
	崔向荣
	井宣
	毕星宇
	张栋栋
	贾洪响
	李艳宏
	战晓宇
	李艳
	王振强
	李晓芳

关键词 ：肥胖, 精液质量, 肿瘤坏死因子α, 白细胞介素6, 男性不育

Abstract：Objective To investigate the potential effect of over-weight and obesity on semen quality mediated TNF-α and IL-6. Methods According to the body mass index values we divided 324 male cases into low-weight group, normal weight group, over-weight group and obese group. Then we determined the semen parameters, sperm morphology, sperm DNA integrity, spermatozoa acrosin activity, seminal plasma zinc, and serum TNF-α and IL-6 levels. Results Compared with normal weight group, the progressive motility in low-weight, over-weight and obese groups was significantly decreased. However, the abnormal head rate in obese group was significantly increased. The sperm spermatozoa acrosin activity and seminal plasma zinc concentration were found significantly decreased in obese group. The serum TNF-α and IL-6 levels were significantly increased in over-weight group and obese group. Both progressive motility and sperm concentration have a nonlinear association with the levels of serum TNF-α and IL-6. Conclusion The decrease in semen quality caused by over-weight and obesity may be mediated by serum TNF-α and IL-6 levels.

Key words： Obesity Semen quality TNF-α IL-6 Male infertility

收稿日期: 2015-06-29

基金资助:公益性行业科研专项支出(201402004);山西省留学人员管理委员会办公室科研资助项目(2012-100)

通讯作者: 崔向荣(cuixiangrong094030@163.com)

引用本文:

武学清, 崔向荣, 井宣, 毕星宇, 张栋栋, 贾洪响, 李艳宏, 战晓宇, 李艳, 王振强, 李晓芳. 肥胖对男性精液质量影响与血清TNF-α及IL-6相关性[J]. 中国生育健康杂志, 2015, 26(6): 508-511.
WU Xueqing, CUI Xiangrong, JING Xuan, BI Xingyu, ZHANG Dongdong, JIA Hongliang, LI Yanhong, ZHAN Xiaoyu, Li Yan, WANG Zhenqiang, LI Xiaofang. The potential effect of smoking on semen quality through TNF-α and IL-6. Chinese Journal of Reproductive Health, 2015, 26(6): 508-511.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2015/V26/I6/508

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