成纤维细胞生长因子-2在非糖尿病性巨大胎儿孕妇的脐血、羊水和胎盘中的表达

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摘要目的观察孕妇脐血血清、羊水、胎盘中成纤维细胞生长因子-2(FGF-2)在非糖尿病性巨大胎儿中的表达,探究其在巨大胎儿发病中的作用。方法选择2013年12月至2014年3月于哈尔滨医科大学附属第四医院产前检查并分娩的初产妇,收集妊娠足月、新生儿出生体质量≥4 000 g的孕妇的脐血、羊水及胎盘15例为巨大胎儿组,收集妊娠足月、新生儿出生体质量在2 500～3 999 g的孕妇的脐血、羊水及胎盘15例为正常组。脐血、羊水应用酶联免疫吸附剂测定FGF-2的水平,胎盘应用免疫组化法检测FGF-2的表达,并进行对比分析。结果巨大胎儿组脐血FGF-2水平为[(3.5±5.5)pg／ml],正常组脐血FGF-2水平为[( 2.3±3.6)pg／ml],巨大胎儿组脐血中FGF-2的水平略高于正常组,两组比较差异无统计学意义;巨大胎儿组羊水FGF-2水平为[(0.5±0.4)pg／ml],正常组羊水FGF-2水平为[(0.1±0.5)pg／ml],巨大胎儿组羊水中FGF-2的水平明显高于正常组,两组比较差异有统计学意义。巨大胎儿组产妇胎盘FGF-2表达较对照组降低,两组比较差异有统计学意义。结论非糖尿病性巨大胎儿组孕妇脐血、羊水、胎盘中均有FGF-2表达,羊水、胎盘中FGF-2的水平可能与非糖尿病性巨大胎儿的发病有关,脐血中FGF-2水平与非糖尿病性巨大胎儿的关系还有待加大样本的深入研究。

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关键词 ：非糖尿病孕妇, 巨大胎儿, 成纤维细胞生长因子-2

收稿日期: 2014-11-24

通讯作者: 蔡雁(caiyan318@126.com)

引用本文:

高艳, 蔡雁. 成纤维细胞生长因子-2在非糖尿病性巨大胎儿孕妇的脐血、羊水和胎盘中的表达[J]. 中国生育健康杂志, 2015, 26(4): 354-356.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2015/V26/I4/354

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