河北省汉族女性亚甲基四氢叶酸还原酶与甲硫氨酸合成酶还原酶基因多态性

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摘要目的探讨河北省汉族女性亚甲基四氢叶酸还原酶(MTHFR)和甲硫氨酸合成酶还原酶(MTRR)基因多态性的频率特征,以指导孕妇增补叶酸和出生缺陷一级预防。方法选取河北省廊坊、张家口、承德三个地区的5 562名汉族女性,检测MTHFR C677T、A1298C和MTRR A66G基因多态性,分析频率分布特征,与已报道的其他地区数据进行比较。结果河北省汉族女性的MTHFR 677TT纯合突变基因型频率(34.9%)高于烟台(32.2%)、延边(28.3%)、镇江(21.8%)、松滋(15.4%)、德阳(13.8%)、广州(7.4%)、琼海(6.1%),低于淄博(43.6%)、潍坊(38.8%),河北省内3个地区比较,差异无统计学意义。MTHFR 1298CC纯合突变基因型频率(2.0%)高于淄博(1.4%)和潍坊(1.3%),低于延边(3.8%)、镇江(3.5%)、松滋(2.6%)、德阳(6.3%)、广州(5.3%)、琼海(7.1%),等位基因频率与淄博、镇江、松滋、德阳、广州和琼海等比较,差异有统计学意义;MTRR 66GG纯合突变基因型频率(6.4%)低于德阳(8.2%)、广州(7.7%)和琼海(9.3%),等位基因频率与淄博、潍坊、松滋、德阳、广州和琼海汉族女性的差异有统计学意义。结论河北省汉族女性MTHFR和MTRR基因多态性频率分布具有地域特异性。

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	李进华
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	马少杰
	鲁衍强

关键词 ：亚甲基四氢叶酸还原酶, 甲硫氨酸合成酶还原酶, 单核苷酸多态性

Abstract：Objective To describe the genotype distribution of MTHFR and MTRR among Chinese Han women in Hebei province. Methods 5 562 DNA samples were collected from women in Langfang, Zhangjiakou and Chengde city, Hebei province. The distribution of MTHFR C677T, A1298C, and MTRR A66G genotypes was tabulated and compared with the results reported in Chinese in other regions. Results The frequency of MTHFR 677TT genotype was no statistical differences among the three cities in Hebei province. However, the overall TT genotype in Hebei was higher than that in Yantai, Yanbian, Zhenjiang, Songzi, Deyang, Guangzhou, and Qionghai, but lower than that in Zibo and Weifang. The frequency of MTHFR 1298CC genotype in Hebei was higher than that in Zibo and Weifang, but lower than that in Yanbian, Zhenjiang, Songzi, Deyang, Guangzhou, and Qionghai. The frequency of MTRR 66GG genotype in Hebei was lower than that in Deyang, Guangzhou, and Qionghai. Conclusion The polymorphisms of MTHFR C677T, A1298C, and MTRR A66G among Han women in Hebei province were different from other regions of China.

Key words： Methylenetetrahydrofolate reductase Methionine synthase reductase Single nucleotide polymorphism

收稿日期: 2014-09-28

通讯作者: 鲁衍强(luyanqiang@genechina.com)

引用本文:

李进华, 胡华梁, 范松丽, 赵丽娜, 马少杰, 鲁衍强. 河北省汉族女性亚甲基四氢叶酸还原酶与甲硫氨酸合成酶还原酶基因多态性[J]. 中国生育健康杂志, 2015, 26(3): 219-222.
LI Jinhua, HU Hualiang, FAN Songli, ZHAO Lina, MA Shaojie, LU Yanqiang. Geographical distribution of MTHFR and MTRR gene polymorphisms among Han women in Hebei province. Chinese Journal of Reproductive Health, 2015, 26(3): 219-222.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2015/V26/I3/219

1 钟南山.浅谈我国出生缺陷研究的现况与展望.中国优生优育,2007,13:10-11.
2 卫生部.卫生部发布《中国出生缺陷防治报告(2012)》.中国药房,2012,39:3693.
3 Moore LL,Bradlee ML,Singer MR,et al.Folate intake and the risk of neural tube defects an estimation of dose-response.Epidemiology,2003,14:200-205.
4 贺先民,张群,杨琦,等.亚甲基四氢叶酸还原酶和甲硫氨酸合成酶还原酶基因多态性研究.中国计划生育学杂志,2010,18:13-18.
5 保睿,吴建新.人类神经管缺陷分子遗传学研究进展.中国优生与遗传杂志,2009,17:1-4.
6 尹璐,吕永刚.亚甲基四氢叶酸还原酶基因多态性与自然流产的相关性分析.吉林医学,2012,33:4520-4521.
7 左金玲,易建平,陈宝丽.妊娠高血压综合征基因遗传学研究进展.中国妇幼保健,2011,26:3822-3824.
8 从玉英,鲁衍强,芮欣忆,等.淄博市汉族女性亚甲基四氢叶酸还原酶和甲硫氨酸合成酶还原酶基因多态性分布研究.现代妇产科进展,2012,21:779-781.
9 修霞,牟莹莹,陶华娟,等.潍坊地区孕期女性叶酸利用能力调查.山东医药,2013,53:31-33.
10 严倩,鲁衍强,李瑛,等.烟台市汉族女性MTHFR和MTRR基因多态性的分布特征.山东大学学报(医学版),2014,52:1-6.
11 于延辉,鲁衍强,李瑛,等.延边朝鲜族自治州汉族女性和朝鲜族女性MTHFR与MTRR基因多态性分布研究.实用医学杂志,2014,30:7-9.
12 杨彦,鲁衍强,芮欣忆,等.镇江市汉族女性MTHFR和MTRR基因多态性分布研究.南京医科大学学报:自然科学版,2012,32:1250-1253.
13 罗秀莉,鲁衍强,郭文竹,等.湖北松滋市汉族女性MTHFR与MTRR基因多态性分布.公共卫生与预防医学,2014,25:29-32.
14 张勇,朱正英,王玮,等.四川德阳地区汉族女性人群MTHFR和MTRR基因多态性研究.中国循证医学杂志,2012,12:631-634.
15 尹爱华,鲁衍强,芮欣忆,等.广东省女性亚甲基四氢叶酸还原酶和甲硫氨酸合成酶还原酶基因多态性分布研究.中国公共卫生,2012,28:44-46.
16 颜珠苗,鲁衍强,李瑛,等.琼海市汉族女性MTHFR和MTRR基因多态性分布研究.海南医学院学报,2013,19:18-20.
17 张婷,谢渊,李毅,等.贵州3个民族亚甲基四氢叶酸还原酶基因的遗传多态性.重庆医学,2013,42:3413-3415.
18 李进华,张英奎,赵丽娜,等.2001~2012年河北省主要出生缺陷发生率及变化趋势分析.中国妇幼保健,2013,28:4767-4771.
19 Ali A,Singh SK,Raman R.MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT,but not MTHFR A1298C,are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population.Genet Test Mol Bioma,2009,13:355-360.
20 Centers for Disease Control and Prevention.Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects.MMWR,1992,41(No.RR-14):1-7.