Abstract：Objective To explore the relationship of chromosome anomaly and polymorphism with adverse pregnancy outcomes. Methods Cytogenetic data for 1 191 couples with adverse pregnancy outcomes who visited Sichuan Provincial Hospital for Women and Children during August 2008 to March 2013 were reviewed and analyzed. Peripheral blood lymphocyte culture and harvest were performed according to standard methods. Karyotypes were analyzed by G-banding in all cases and C- banding in some cases. Results Of the 1 191 cases examined, forty-four cases had abnormal chromosome (3.7%) and 145 cases had polymorphic variations (12.2%). Chromosome polymorphic variations accounted for 76.7% of all chromosome karyotypes. Among them, 84 cases showed D/G set with body variant, 36 cases had increases in secondary constriction, 8 cases had increased satellite, 7 cases showed inversion of the ninth chromosomes, 7 case had large Y chromosome, 2 cases showed inversion of the Y chromosomes, and 1 case had X chromosome with body variant. Conclusion Chromosome anomalies were common among couples with repeated spontaneous abortion, embryo arrest, stillbirth, and fetal or infant malformations.
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