Abstract:Objective To investigate the clinical features and pathological types of postmenopausal endometrial thickening patients and to analyze the risk of endometrial malignancy.Methods 523 cases of postmenopausal women with endometrial thickening were recruited from January 2017 to August 2018. According to the pathological results of hysteroscopy, the risk of endometrial malignancy was analyzed.Results The pathological diagnosis of 523 postmenopausal endometrial thickening patients included 24 cases of normal endometrium (4.6%), 268 cases of endometrial polyps (51.2%), 44 cases of endometritis (8.4%), 16 cases of submucous myomas (3.1%), 53 cases of intrauterine adhesions (10.1%), 89 cases of benign endometrial hyperplasia (17.0%), 13 cases of atypical endometrial hyperplasia (2.5 %) and 16 cases of endometrial carcinoma (3.1 %).BMI≥25, vaginal bleeding or drainage symptoms, and endometrial thickness≥10 mm were independent risk factors for endometrial malignancy (P<0.05 ).Conclusion Attention should be paid to the high risk factors of endometrial cancer, and it’s necessary to perform hysteroscopy to detect endometrial malignant lesions and to reduce invasive procedures for patients without endometrial lesions, which could reduce the suffering of patients and wasting medical resources.
尹聪, 白文佩. 绝经后子宫内膜增厚患者内膜恶变风险分析[J]. 中国生育健康杂志, 2019, 30(3): 215-217.
YIN Cong,BAI Wenpei. Clinical Characteristics of Endometrial cancer among Postmenopausal Women with Endometrial Thickening. Chinese Journal of Reproductive Health, 2019, 30(3): 215-217.
1 Silvestri C,Di Marzo V.The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders.Cell Metab,2013,17:475-490. 2 Alswat KA.The role of endocannabinoids system in fatty liver disease and therapeutic potentials.Saudi J Gastroenterol,2013,19:144-151. 3 Bouzid A,Ayachi A,Mourali M.Value of ultrasonography to predict the endometrial cancer in postmenopausal bleeding.Gynecol Obstet Fertil,2015,43:652-658. 4 Chen W,Zheng R,Baade PD,et al.Cancer statistics in China.CA cancer J Clin,2016,66:115-132. 5 Wu M,Shen K,,Lang JH.Analysis of post-menopausal bleeding and high-risk factors of endometrial cancer.Chin J obstet Gynecol,2005,40:487-488. 6 Kim W,Doyle ME,Liu Z,et al.Cannabinoids inhibit insulin receptor signaling in pancreatic β—cells.Diabetes,2011,60:1198-1209. 7 Giannella L,Mfuta k,Setti T,et al.Diagnostic accuracy of endometrial thickness for the detection of intra-uterine pathologies and appropriateness of performed hysteroscopies among asymptomatic postmenopausal women.Eur J Obstet Gynecol Reprod Biol,2014,177:29-33. 8 王田华,张慧英.绝经后子宫内膜增厚的研究进展.国际生殖健康/计划生育杂,2017,36:349-352. 9 Remondi C,Sesti F,Bonanno E,et al.Diagnostic accuracy of liquid-based endometrial cytology in the evaluation of endometrial pathology in postmenopausal women.Cytopathol,2013,24:365-371. 10 马辛欣,王建六.子宫内膜癌诊断方法.国际妇产科杂志,2014,41:410-413. 11 Billingsley CC,Kenne KA,Cabsino CD,et al.The use of transvaginal ulterasound in type II endometrial cancer.Int J Gynecol Cancer,2015,25:858-862. 12 李雷,吴鸣.绝经后女性子宫内膜厚度与内膜癌风险的相关性.中华肿瘤杂志,2017,39:481-484.