自噬调节基因<i>AMBRA1</i>在神经管发育中的作用及机制研究进展

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摘要神经管畸形(NTDs)是在胚胎发育过程中,由于神经管闭合缺陷导致的先天性畸形。在神经管闭合过程中,自噬是必不可少的。许多研究表明,自噬/苄氯素1调节因子1基因(AMBRA1)编码的蛋白质在自噬调节过程中发挥着重要作用。AMBRA1基因缺失导致胚胎发育早期自噬损伤,发生严重NTDs表型。本文从自噬角度对AMBRA1基因在神经管发育过程中的作用及其机制进行综述,以期为进一步阐明NTDs的发生机制提供新思路。

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	秦佳星
	牛勃
	王建华

关键词 ：神经管畸形, 细胞自噬, 胚胎发育, 自噬/苄氯素1调节因子1基因

收稿日期: 2018-05-14

基金资助:国家自然科学基金资助项目(81571443,81600984);北京市自然科学基金资助项目(7172038,7174285)

通讯作者: 王建华(fywjh@163.com)

引用本文:

秦佳星，牛勃，王建华. 自噬调节基因AMBRA1在神经管发育中的作用及机制研究进展[J]. 中国生育健康杂志, 2019, 30(4): 386-388.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2019/V30/I4/386

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