1 Fauser BC,Tarlatzis BC,Rebar RW,et al.Consensus on women's health aspects of polycystic ovary syndrome (PCOS) :the amsterdam ESHRE/ASRM-sponsored 3rd PCOS consensus workshop group.Fertil Steril,2012,97:28-38,e25. 2 Conway G,Dewailly D,Diamanti-Kandarakis E,et al.The polycystic ovary syndrome:a position statement from the European Society of Endocrinology.Eur J Endocrinol,2014,171:1-2. 3 Ebejer K,Callejaagius J.The role of cytokines in polycystic ovarian syndrome.Gynecol Endocrinol,2013,29:536-540. 4 Stein SC,Woods A,Jones NA,et al.The regulation of AMP-activated protein kinase by phosphorylation.Biochem J,2000,345:437-443. 5 Ewart MA,Kennedy S.AMPK and vasculoprotection.Pharmacol Ther,2011,131:242-253. 6 Carling D,Thornton C,Woods A,et al.AMP-activated protein kinase:new regulation,new roles?.Biochem J,2012,445:11-27. 7 Hardie DG,Ross FA,Hawley SA.AMPK:a nutrient and energy sensor that maintains energy homeostasis.Nat Rev Mol Cell Biol,2012,13:251-262. 8 Jeon SM.Regulation and function of AMPK in physiology and diseases.Exp Mol Med,2016,48:e245. 9 Habets DD,Coumans WA,EL Hasnaoui M,et al.Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyo-cytes.Biochim Biophys Acta,2009,1791:212-219. 10 Lin ZM,Jiao LZ,Zheng Y,et al.The effect and mechanism of curcu min derivative B06 on the myocardium from type 2 diabetic rats.Zhongguo Ying Yong Sheng Li Xue Za Zhi,2014,30:38-42. 11 Yang Z,Kahn BB,Shi H,et al.Macrophage α1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem,2010,285:19051-19059. 12 Meares GP,Qin H,Liu Y,et al.AMP-activated protein kinase restricts IFN-γ signaling.J Immunol,2013,190:372-80. 13 Bertoldo MJ,Faure M,Dupont J,et al.AMPK:a master energy regulator for gonadal function.Front Neurosci,2015,9:235. 14 Richardson MC,Ingamells S,Simonis CD,et al.Stimulation of lactate production in human granulosa cells by metformin and potential involvement of adenosine 5' monophosphate-activated protein kinase.J Clin Endocrinol Metab,2009,94:670-677. 15 Ya R,Downs SM.Perturbing microtubule integrity blocks AMP-activated protein kinase-induced meiotic resumption in cultured mouse oocytes.Zygote,2014,22:91-102. 16 Winterhager E,Kidder GM.Gap junction connexins in female reproductive organs:implications for women's reproductive health.Hum Reprod,2015,21:340-352. 17 Bertoldo MJ,Guibert E,Faure M,et al.Specific deletion of AMP-activated protein kinase (α1AMPK) in murine oocytes alters junctional protein expression and mitochindrial physiology.PLos One,2015,10:e0119680. 18 Tosca L,Chabrolle C,Dupont J.[AMPK:a link between metabolism and reproduction?].Medecine Sciences,2008,24:297-300. 19 Fu LL,Xu Y,Li DD,et al.Expression profiles of mRNA and long noncoding RNA in the ovaries of letrozole-induced polycystic ovary syndrome rat model through deep sequencing.Gene,2018,30:19-29. 20 Tao X,Chen L,Cai Ls,et al.Regulatory effects of the AMPKα-SIRT1 molecular pathway on insulin resistance in PCOS mice:An in vitro and in vivo study.Biochem Biophys Res Commun,2017,494:615-620. 21 Eng GS,Sheridan RA,Wyman A,et al.AMPK activation increases glucose uptake,decreases apoptosis and improves pregnancy outcome in embryos exposed to high IGF-1 concentrations.Diabetes,2007,57:2228-2234. 22 Pradeep PK,Li X,Peegel H,et al.Dihydrotestosterone inhibits granulosa cell proliferation by decreasing the cyclin D2 mRNA expression and cell cycle arrest at G1 phase.Endocrinology,2002,143:2930-2935. 23 Kayampilly PP,Menon KM.AMPK activation by dihydrotestosterone reduces FSH-stimulated cell proliferation in rat granulosa cells by inhibiting ERK signaling pathway.Endocrinology,2012,153:2831-2838.