核苷酸结合寡聚结构域样受体蛋白3炎症小体在妇科疾病中的研究进展

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摘要炎症小体能够调节固有免疫系统,参与宿主抵抗病原体和细胞损伤的免疫应答,在人类许多疾病的发生与发展中起着不可或缺的作用。核苷酸结合寡聚结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)炎症小体是能被多种病原物质所激活的多蛋白复合物,活化后的NLRP3能够促进组织中白细胞介素(IL)-1β和IL-18的表达上调,进而介导相关的人类炎性疾病的发生与发展。本文描述了NLRP3炎症小体的结构和功能,并概述其在妇科疾病中的研究认识,从而提出NLRP3炎症小体可能成为诊疗妇科疾病新的潜在靶点,为妇科疾病的发病机制和治疗提供更多新的研究思路。

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	冯晓玲
	朱娣
	张杨

关键词 ：核苷酸结合寡聚结构域样受体蛋白3(NLRP3), 炎症小体, 白细胞介素-1β, 白细胞介素-18, 妇科疾病

收稿日期: 2019-11-11

基金资助:国家自然科学基金(81574014)

通讯作者: 张杨(196667124@qq.com)

引用本文:

冯晓玲, 朱娣, 张杨. 核苷酸结合寡聚结构域样受体蛋白3炎症小体在妇科疾病中的研究进展[J]. 中国生育健康杂志, 2021, 32(2): 190-193.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2021/V32/I2/190

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