Abstract:Objective In order to find the risk factors of recurrent implantation failure and to reduce the incidence of recurrent implantation failure by retrospective analysis of the clinical data of the patients with recurrent implantation failure.Methods 196 cases who were diagnosed as recurrent implantation failure during 2015-2016, and 392 patients with successful pregnancy of their first IVF cycle which was preformed at the same month with recurrent implantation failure patients were selected as the control group. The clinical data of the two groups were analyzed, including basic information, the cause of infertility and the first IVF cycle-related information. Besides, according to patients' age, we analyze the clinical data in each group.Results Patients' husband age and endometriosis are risk factors for recurrent implantation failure, while the 2PN rate, the rate of good quality embryo and A pattern of the endometrium are protective factors for recurrent implantation failure. Analysis on Stratification of Age revealed that the age of the husband and ISCI-2PN rate had statistical significance in Group A, and anovulatory infertility, male factors, high quality embryos, total 2PN rate, IVF-2PN rate, ICSI-2PN rate and high quality embryo rate were significantly different in Group B, and there were significant differences in androgen levels, endometrial thickness, total oocytes count and 2PN numbers in Group C.Conclusion The higher the age of the husband, the higher the risk of recurrent implantation failure, and the infertile patients combined with endometriosis are prone to recurrent implantation failure. While the success rate of IVF assisted pregnancy was high in patients with high fertilization rate, good embryo quality and A pattern endometrium. In addition, stratification management according to the patients' age should be used.
贾婉璐, 王海燕, 乔杰, 刘平, 李蓉, 陈新娜, 王颖. 反复着床失败患者的临床病例对照研究[J]. 中国生育健康杂志, 2024, 35(1): 40-47.
JIA Wanlu, WANG Haiyan, QIAO Jie, LIU Ping, LI Rong, CHEN Xinna, WANG Ying. Clinical case-control study in patients with recurrent implantation failure. Chinese Journal of Reproductive Health, 2024, 35(1): 40-47.
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