Objective We aimed to explore the clinical efficacy of LEEP operation combined with Qilin TCM decoction on decreasing of postoperative complications, improve TCM syndrome, promoting HPV clearance and cervical intraepithelial lesions (CIN) recovery. Methods A total of 400 cases with CIN I-II after LEEP operation, according with TCM diagnostic standards of morbid leukorrhea disease (dampness heat with blood toxin stasis type) were randomly divided into 4 groups (Qilin TCM decoction groups, Baofukang suppository group, Qilin TCM decoction combined with Baofukang suppository group, blank control group, 100 cases in each group). All participants were given corresponding adjuvant therapy for three courses,regularly followed up at 2、1、3、6 and 12 months after operation, Postoperative complications、improvement of TCM syndromes, cervical HPV clearance、cytology (TCT) recovery and prognosis of cervical precancerous lesions(CIN)were compared among the fours groups. Results A total of 360 cases were collected. Among them, there were 95 cases in Qilin TCM decoction group, 94 cases in Baofukang suppository group, 92 cases in Qilin TCM decoction combined with Baofukang suppository group, 79 cases in blank control group. The incidence of cervical infection and bleeding complications in combined medication group (4.4%、6.5%)and Qilin TCM decoction Group (6.3%、7.4%) was significantly lower than that in Baofukang suppository group (7.5%, 10.6%) and blank control group (11.4%, 12.7%), but there was no significant difference between the combined medication group and the Qilin TCM decoction Group(4.4%/6.3%、6.5%/7.4%,P>0.05); The improvement rate of TCM syndrome in combined medication group and Qilin TCM decoction Group was significantly higher than that in Baofukang suppository group and blank control group, respectively (P <0.05), but there was no significant difference between combined medication group and Qilin TCM decoction Group (P>0.05). HPV clearance rate, recovery rate of TCT, total effective treatmentrate of CIN in combined medication group (91.3%, 90.2%, 93.5%) were significantly higher than those in Qilin TCM decoction Group (85.3%, 82.1%, 85.3%), Baofukang suppository group (73.4%, 69.2%, 75.5%) and blank control group (67.1%, 63.3%, 70.1%), respectively. Conclusion LEEP operation combined with Qilin TCM Decoction and Bafukang suppository to treat CIN I-II patients is more effective in anti-tumor, anti-virus, anti-inflammatory and enhancing immunity, and effectively decreases postoperative complications, improves leucorrhea and whole body TCM Syndrome, scavenge HPV virus, expedites the recovery of cervical cytology (TCT), promotes the transformation of cervical atypical hyperplasia to normal tissue,it is worthy of clinical application.