Welcome to visit Chinese Journal of Reproductive Health!Today is

11 July 2026, Volume 37 Issue 4
    

  • Select all
    |
  • LIANG Junhao, SHUI Yanli, ZHOU Yubo, ZHAO Tingting, ZHANG Lirong, LI Hongtian, LU Shichun, LIU Jianmeng
    Chinese Journal of Reproductive Health. 2026, 37(4): 301-309.
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective The aims of this study were to describe the cesarean section rates according to key obstetric characteristics, estimate their contributions to the overall rate, and analyze the recorded indications for performing cesarean sections in low-risk women, demonstrating the typical characteristics of cesarean sections performed in similar institutions and ascertaining crucial populations to control cesarean overuses. Methods A descriptive study. This study included all women who delivered babies at a referral hospital in Anhui between July 2017 and April 2024. Maternal demographic characteristics, obstetric characteristics, and delivery modes were extracted from medical records. Women were first stratified into nulliparous and multiparous groups. They were then divided into eight groups according to modified Robson classification. ≥37 weeks gestation, singleton, cephalic nulliparous women were defined as low-risk women. The primary outcomes were the obstetric-characteristic-specific cesarean section rates, their proportional contributions to the overall cesarean rate, and the distribution of recorded indications among low-risk women. Results A total of 48 627 women were included, with 54.4% being multiparous and 45.6% nulliparous. The cesarean section rate were 37.9% overall, 46.3% for multiparous women, 27.8% for the nulliparous(P<0.001 for multiparous vs. nulliparous), and 23.2% for the low-risk women. The cesarean rate for ≥37 weeks gestation, singleton, cephalic and multiparous women with a uterine scar was 94.1%, being 16.8 times that for the women without a scar(5.6%, P<0.001). The cesarean rates for women with other key obstetric characteristics, including transverse lie, breech, and multiple pregnancy, all stayed high, ranging from 88.3% to 97.4%, despite whether they were multiparous or nulliparous. After adjusting population compositions, the proportional contribution to the overall cesarean rate were 52.3% for ≥37 weeks gestation, singleton, cephalic and multiparous women with a uterine scar, 25.4% for ≥37 weeks gestation, singleton, cephalic and nulliparous women, and 9.6% for all singleton breech women. The contribution made by women with transverse lie or multiple pregnancies, due to the low prevalence in population, was only about 3.0%. In stratified analyses, ≥37 weeks gestation, singleton, and cephalic women with a uterine scar contributed 78.6% to the cesarean rate for multiparous women, and corresponding figure was 75.8% for nulliparous women, i.e. low-risk women. Of the low-risk women with cesarean section, 13.4% had no indications; and other most commonly recorded indications were fetal distress(21.6%), cephalopelvic disproportion(15.4%), and dystocia(10.9%). Conclusion The overall rate of cesarean section was 19% lower than the national average for referral institutions, and the rate for low-risk women was even close to that in Japan or Finland known as low cesarean nations, strongly indicating that the overuse of cesarean section in China could be controlled. To control the overuse, low-risk nulliparous women, ≥37 weeks gestation, singleton, cephalic, multiparous women with a uterine scar, and women with a singleton breech should be targeted. Herein low-risk nulliparous women recorded indications for performing cesarean sections, such as fetal distress and cephalopelvic disproportion, merited further evaluation.
  • CHE Qi , WANG Lin, LIU Miao, LIU Suying,DONG Xi
    Chinese Journal of Reproductive Health. 2026, 37(4): 310-316.
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective To explore the differences of expression of long chain non coding RNA(lncRNA) in ovarian granulosa cells of patients with polycystic ovary syndrome(PCOS) and to observe the therapeutic effect in a rat model. Methods Follicular fluid was collected from patients undergoing vitro fertilization-embryo transfer(IVF) or intracytoplasmic sperm injection(ICSI) at reproductive medicine center in Zhongshan Hospital, Fudan University. 4 cases in the PCOS group and 4 cases with normal ovarian function in the control group were included. Ovarian granulosa cells were extracted, and lncRNA chips were used to screen expression of lncRNAs and compared between the two groups of granulosa cells. A PCOS rat model was established by injecting dehydroepiandrosterone(DHEA), and lentiviral shRNA targeting lncRNA-ZSCAN2-5∶15 was prepared. The lentivirus with the most significant interference effect was selected for subcapsular injection into the rat ovary, and the therapeutic effect of the PCOS rat model after interference was observed. Results The results of lncRNA chip screening showed that there were 879 lncRNAs upregulated and 4 569 lncRNAs downregulated significantly in the PCOS group compared to the control group of granulosa cells. lncRNA-ZSCAN2-5∶15, which is statistical significance significantly in differential expression, was selected for rat experiment. The interference effects of three shRNA sequences on the expression of lncRNA-ZSCAN2-5∶15 were compared, and one sequence was found to significantly downregulate its expression(P<0.01). After injecting shRNA into the ovarian tissue of the PCOS rat model, both gross examination and histological section HE staining of the ovarian tissue showed that downregulation of lncRNA-ZSCAN2-5∶15 expression effectively improved the clinical phenotype and sex hormone levels of the PCOS rats. Conclusion There are significant changes in lncRNA expression in ovarian granulosa cells of PCOS patients compared to controls. Blocking specifically elevated lncRNA could effectively improve the clinical symptoms of the PCOS rat model and provide new treatment possibility for the clinical treatment of PCOS.
  • ZHANG Ziyi, YANG Zeping, WANG Yiran, LI Tong, ZHANG Le, ZHANG Yali, LI Zhiwen, YE Rongwei, LI Nan
    Chinese Journal of Reproductive Health. 2026, 37(4): 317-323.
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective The aim of this study was to investigate the association between periconceptional 2.5-micrometer particulate matter(PM2.5) exposure levels in pregnant women and the risk of anemia associated with offspring at 6 and 12 months of age. Methods This study was based on Perinatal Health Care Surveillance System data established by Peking University Institute of Reproductive and Child Health in collaboration with US Centers for Disease Control and Prevention, and used a retrospective cohort study design to conduct secondary analysis of data from the Pregnancy Nutrition Program. The study included 17 163 mother-child pairs from five counties in Hebei Province between May 2006 and April 2009. PM2.5 data were obtained from Tracking air pollution in China(TAP).The study subjects were stratified by exposure concentration percentiles, and the exposed and non-exposed groups were defined using the quartile method. Cox proportional risk model was used to analyze the association between periconceptional PM2.5 exposure concentration levels and anemia in offspring at 6 and 12 months of age, and the hazard ratio(HR) and 95% confidence interval(CI) were calculated. Potential confounding variables were stratified and potential nonlinear associations between PM2.5 and offspring anemia were analyzed using restricted cubic spline models. Results The Cox proportional hazards model found that each 1 standard deviation increase in PM2.5 exposure during the pre-conception trimesters (34.03 μg/m3) were significantly associated with an increased risk of anemia in the offspring at 6 months of age (HR=1.39, 95% CI: 1.24-1.56), and each 1 standard deviation increase in PM2.5 exposure during the post-conception trimesters (33.34 μg/m3) significantly increased the risk of anemia development in the offspring at 12 months of age (HR=1.29, 95% CI: 1.13-1.49). Exposure to PM2.5 in the post-conception trimester increased the risk of anemia in the offspring at 6 months of agein all individuals who are not exclusively breastfed, and exposure to high levels of PM2.5 in the post-conception trimester significantly increased the risk of anemia in the offspring at 12 months of age in people who were exclusively breastfed. Periconceptional PM2.5 exposure showed a nonlinear dose-response relationship with anemia in offspring at both 6 and 12 months of age. Conclusion Elevated PM2.5 exposure in pregnant women during the pre-conception trimester significantly increased the risk of anemia in offspring at 6 months of age, and elevated PM2.5 exposure during the post-conception trimester significantly increased the risk of anemia in offspring at 12 months of age.
  • BU Xiaoling, WANG Qianyi, YU Yanyan, LU Jie,QIN Luxue, YANG Yan
    Chinese Journal of Reproductive Health. 2026, 37(4): 324-330.
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective To analyze the impact of clinical characteristics, social psychological and quality of life(QOL) factors on endometrial receptivity(ER) Salle scores in infertile patients. Methods A total of 200 infertile patients aged 20-40 years who visited the Dongfang Hospital of Beijing University of Chinese Medicines from September 2022 to April 2024 were enrolled. According to Salle score, the patients were divided into ER positive group(The Salle score <13) and ER negative group(the Salle score ≥13), with 100 cases in each group. Clinical data and social, psychological and QOL scales, were collected to analyze the clinical characteristics and social psychological and QOL factors affecting endometrial receptivity. Results There were statistically significant differences between the two groups in age, menstrual conditions, endometrial thickness, uterine artery pulsatility index(PI), negative emotion and social inhibition score, trait anxiety score, HAMD score, social support score and fertility QOL score(P<0.05). Binary logistic regression analysis revealed that among infertility patients, advanced age(OR=1.28, 95% CI:1.02-1.60), higher uterine artery PI(OR=3.36, 95% CI:1.27-8.88), anxiety(OR=1.12, 95% CI:1.03-1.23), and severe depressive state(OR=1.50, 95% CI:1.15-1.97) were independent risk factors for reduced ER, while regular menstruation(OR=0.17, 95% CI:0.03-0.80), thicker endometrium within a certain range(OR=0.002, 95% CI:0.00-0.59), and higher social support(OR=0.87, 95% CI:0.77-0.98) were protective factors for ER. Conclusion Infertility, as a psychosomatic disease, falls within the category of "emotional illness" in traditional Chinese medicine. Psychological counseling, social support, and traditional Chinese medicine treatments related to emotional regulation can improve endometrial receptivity, creating better conditions for promoting reproduction.
  • ZHANG Qiannan, CHAI Menghan, XIONG Ming, ZOU Huijuan, ZHANG Zhiguo, CHEN Beili
    Chinese Journal of Reproductive Health. 2026, 37(4): 331-335.
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective To investigate the correlation between sperm DNA fragmentation index(DFI) and pregnancy outcomes in teratozoospermia patients undergoing assisted reproductive technology(ART), and to determine the optimal fertilization method(IVF or ICSI) for patients with varying DFI levels. Methods A retrospective analysis was conducted on 1,075 teratozoospermia patients at Reproductive Medicine Center of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui, from Jan 2019 to Dec 2022. Patients were stratified into two groups based on DFI levels:low DFI(<30%, n=976) and high DFI(≥30%, n=99). Analyze the correlation between DFI levels and clinical outcomes of ART. Further subgroup analysis was performed based on fertilization method:IVF(n=387 in low DFI, n=16 in high DFI) and ICSI(n=589 in low DFI, n=83 in high DFI). The primary outcomes measured were embryo implantation rate, clinical pregnancy rate, fertilization rate, and quality embryo rate. Statistical analyses were performed to assess the impact of DFI levels and fertilization methods on ART outcomes. Results In teratozoospermia patients, advancing age was significantly associated with increased DFI levels(P<0.05), reduced sperm concentration, and decreased forward motility(P<0.05). The low DFI group demonstrated significantly higher embryo implantation rates and clinical pregnancy rates compared to the high DFI group(P<0.05). Within the low DFI group, the IVF subgroup exhibited a higher embryo implantation rate than the ICSI subgroup(P<0.05), while the ICSI subgroup achieved a higher fertilization rate(P<0.05). In the high DFI group, the IVF subgroup showed superior quality embryo rates and embryo implantation rates compared to the ICSI subgroup(P<0.05), with no significant differences observed in other parameters. Conclusion In patients with teratospermia, elevated sperm DNA fragmentation index(DFI) levels adversely affect clinical pregnancy outcomes. Moreover, for teratospermia patients with varying DFI levels, ICSI(intracytoplasmic sperm injection) does not improve assisted reproductive outcomes and should therefore be used with caution.
  • ZHOU Jingchao, WANG Qingping
    Chinese Journal of Reproductive Health. 2026, 37(4): 336-342.
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective Screen and identify novel potential biomarkers for ovarian cancer, thereby providing a theoretical basis for assessing the occurrence, progression, and prognosis. Methods Ovarian cancer transcriptomic datasets were downloaded from the GEO public database for differential gene expression analysis, yielding a set of differentially expressed genes(DEGs). Large-scale sample analyses of gene expression differences, protein expression differences, and survival prognosis were conducted using public data analysis platforms, including GEPIA, KM-plot, and UALCAN, to identify stably and highly expressed DEGs. Experimental validation via immunohistochemistry was performed using the HPA database. Results Differential gene analysis revealed significant expression changes in ovarian cancer. Combined with protein expression and survival analyses results, DTX3L was identified as the core gene for subsequent research. Immunohistochemistry detection confirmed that DTX3L expression was significantly higher in ovarian cancer tissues than in normal ovarian tissues(P<0.05). Conclusion The DTX3L gene, identified through bioinformatics screening, exhibits elevated expression in ovarian cancer and may serve as a molecular biomarker for prognostic analysis of this malignancy.
  • WANG Lu, ZHAO Hai, SUN Bingjie, XIA Zhiwei
    Chinese Journal of Reproductive Health. 2026, 37(4): 343-347.
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective To explore the correlation between myopia in students and that in their parents, and to provide a theoretical basis for the early screening and intervention of myopia in adolescents. Methods A cluster random sampling method was adopted. From September to November 2024, vision examinations and questionnaire surveys were conducted on a total of 25 369 students from the fourth grade of primary school to the third grade of high school in 95 primary and secondary schools in 16 districts of Beijing. χ2 test was used to compare categorical data between groups in univariable analysis. One-way ANOVA was used to compare the average age of starting to wear glasses among different groups. Multivariable logistic regression models were used to analyze the association between myopia in children and myopia in parents. Results The overall myopia rate among students was 71.8%. The myopia rate of students with neither parent myopia was 61.0%, that of students with one myopia parent was 74.9%, and that of students with both parents were myopia was 84.0%, with statistically significant differences across groups(P<0.01). Parental myopia status was significantly associated with family eye-related behaviors. Compared with students with one or no myopic parents, students with both parents myopic had significantly higher proportions of weekly cultural tutoring attendance of ≥2 hours, higher reduction in children′s exercise time due to homework or attending tutoring, stricter parental restricting on screen time, and more frequent parental reminders regarding reading and writing posture(P<0.01). students with both parents myopic showed lower proportions of sufficient daytime outdoor activity(≥2 hours per day) and adequate sleep(P<0.01). After adjusting for confounding factors including educational stage, residence, gender, daily outdoor time, and sleep duration, multivariable logistic regression analysis showed that, compared with the reference group of no parental myopia, having one myopic parent(OR=1.87, 95%CI:1.71-2.04) and having both parents myopic(OR=3.92, 95%CI:3.59-4.28) were independent risk factors for student myopia. The age at first spectacle wear also differed significantly across the three parental myopia groups(P<0.01). Conclusion Parental myopia, particularly bilateral parental myopia, significantly increases children’s risk of developing myopia. Parental myopia history should be regarded as a key indicator for identifying children and adolescents at high risk of myopia. Targeted early intervention focusing on increased outdoor activity and standardized eye-use behaviors is strongly recommended for this high-risk population.
  • ZHAO Linlin, LIU Zhao, WANG Jin, LI Xia, GAO Weijia
    Chinese Journal of Reproductive Health. 2026, 37(4): 348-353.
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective To investigate the relationship between serum levels of GPR120, TNC and CCN5 with insulin resistance and adverse pregnancy outcomes in patients with gestational diabetes mellitus(GDM). Methods A total of 108 patients with GDM admitted to Beijing Aerospace General Hospital between January 2023 and July 2024 were selected as the study subjects. They were divided into a favourable outcome group(n=76) and an adverse outcome group(n=32) based on pregnancy outcomes. Additionally, 108 pregnant women with normal antenatal check-ups during the same period were selected to form the control group. Serum levels of GPR120, TNC and CCN5 were compared across the groups, and their correlation with clinical indicators was analysed. Multivariate logistic regression was used to identify factors influencing pregnancy outcomes in GDM patients, and receiver operating characteristic(ROC) curves were employed to assess the predictive performance of GPR120, TNC and CCN5 for adverse pregnancy outcomes. Results Compared with the control group, serum levels of GPR120, TNC and CCN5 were elevated in both the favourable-outcome and adverse-outcome groups of women with GDM(P<0.05), and the levels of these markers were higher in the adverse-outcome group than in the favourable-outcome group(P<0.05). Fasting blood glucose(FBG) and the homeostasis model assessment of insulin resistance(HOMA-IR) were higher in the adverse-outcome group than in the favourable-outcome group(P<0.05). Serum levels of GPR120, TNC and CCN5 were positively correlated with both FBG and HOMA-IR(P<0.05). Elevated levels of these three markers were risk factors for adverse pregnancy outcomes in patients with GDM(P<0.05). The areas under the curve(AUC) for predicting adverse pregnancy outcomes using serum GPR120, TNC and CCN5 were 0.853, 0.833 and 0.851, respectively. The AUC for combined prediction was significantly higher than that for each individual marker(Zcombination-GPR120=2.387, P=0.017, Zcombination-TNC=2.901, P=0.004, Zcombination-CCN5=2.822, P=0.005). Conclusion The levels of serum GPR120, TNC, and CCN5 are significantly elevated in GDM patients, and their levels are significantly associated with insulin resistance. The combined detection of serum GPR120, TNC, and CCN5 has high predictive value for adverse pregnancy outcomes in GDM patients.