Effects of maternal serum Hcy on infant cognitive-motor development

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Chinese Journal of Reproductive Health ›› 2024, Vol. 35 ›› Issue (2) : 147-151.

JIANG Xiaoyang, LI Hui, SUN Yu, WANG Xiaoyan, HANG Chumei, YAO Yanfei, YANG Xi, SHAO Ziyu

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Abstract

Objective To explore the relationship between maternal serum homocysteine (Hcy) during second trimester and cognitive-motor development of infants. Methods 594 pregnant women (aged 20~35 years) in their second trimester (15-20⁺⁶ weeks) in Hefei city were enrolled from April to May 2020. Infants′ cognitive-motor development at 6 and 12 months were evaluated through the Age and Developmental Progress Questionnaire (ASQ-3) which five main developmental areas were included, i.e., communication, gross motor, fine motor, problem-solving, and personal-social skills. Pregnancy outcomes and cognitive-motor assessments were collected, and Pearson correlation was used to analyze the correlation between maternal serum Hcy and infants′ cognitive-motor development; linear regression was used to analyze the relationship between maternal serum Hcy and infants′ cognitive-motor development levels. Results There is no statistically significant differences for ASQ-3 score at 6 months by birth weight, preterm birth, and serum Hcy. There was no statistically significant differences for ASQ-3 scores at 12 months by birth weight, preterm birth. The difference in infant fine motor development scores at 12 months was statistically significant when comparing infants with serum Hcy. The results of correlation analysis showed that serum Hcy during pregnancy was statistically negatively correlated with infant fine motor development score at 12 months (r=-0.123, P<0.05). Linear regression analysis showed a statistically significant difference between serum Hcy during pregnancy and infants′ fine motor development score at 12 months of age (β=-0.996, 95% CI:-1.83 to -0.16, P<0.05). Conclusion Maternal serum Hcy was negatively correlated with fine motor development scores of infants at 12 months, and elevated serum Hcy during pregnancy may affect cognitive-motor development of infants.

Key words

homocysteine / pregnant woman / infant / cognitive-motor development

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JIANG Xiaoyang, LI Hui, SUN Yu, WANG Xiaoyan, HANG Chumei, YAO Yanfei, YANG Xi, SHAO Ziyu. Effects of maternal serum Hcy on infant cognitive-motor development[J]. Chinese Journal of Reproductive Health, 2024, 35(2): 147-151

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