Expression and significance of Yes associated protein in endometrial adenocarcinoma

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Chinese Journal of Reproductive Health ›› 2024, Vol. 35 ›› Issue (4) : 318-322.

WANG Wenzhan, ZHANG Sanyuan

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Abstract

Objective To investigate the expression and clinical significance of Yes associated protein(YAP) in endometrial carcinoma. Methods A total of 56 patients with endometrioid adenocarcinoma who underwent comprehensive staging surgery in the First Hospital of Shanxi Medical University from September 2018 to December 2019 were collected. The ages ranged 43-69 years old(median age, 54 years). None of them received radiotherapy or chemotherapy before surgery and were not complicated with other systemic tumors. Immunohistochemistry(IHC) was performed on paraffin-embedded tissue blocks of corresponding cases in the pathological tissue bank to detect the expression of YAP, and the numbers of cases with high and low expression were calculated, respectively. The expression of YAP in endometrial adenocarcinoma tissue and normal adjacent tissue was compared. The relationship between its expression and various clinicopathological parameters was compared using immunohistochemistry, and statistical analysis was performed using SPSS 22.0 to explore the relationship between YAP expression and various clinicopathological features. Results YAP was mainly expressed in the nucleus and cytoplasm, and its expression in cancer tissues was significantly higher than that in adjacent tissues, which was correlated with histological grade, surgical pathological staging, and depth of muscle infiltration(P<0.05). Conclusion YAP is associated with the occurrence and development of endometrial adenocarcinoma and may serve as a new target for clinical treatment.

Key words

YAP / endometrial adenocarcinoma / hippo signaling pathway

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WANG Wenzhan, ZHANG Sanyuan. Expression and significance of Yes associated protein in endometrial adenocarcinoma[J]. Chinese Journal of Reproductive Health, 2024, 35(4): 318-322

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