Objective To investigate the effect of twin pregnancy on the long term risk of hypertension in women. Methods Data were derived from an ongoing twin survey study which aims to recruit 1 000 women and their children who had twin pregnancies during 1990~2010, along with a matched control group of approximately 1 000 women with singleton pregnancy and their children. Women were matched based on the same township and with pregnancy dates within less than a year. Questionnaires data were collected from 1 686 mother from four counties/districts in Hebei Province(Mancheng, Xianghe, Leting, and Fengrun) from Jun 2021 to September 2023. Exclusion criteria included lack of confirmed hypertension diagnosis, diagnosis of hypertension before pregnancy, during pregnancy, or within two years postpartum, and missing critical information such as date of birth, height, weight, lifestyle, and dietary habits. Finally, a total of 1 550 women were included in the analysis. There were 769 women with twin pregnancies(twin group) and 781 women with singleton pregnancies(singleton group). Basic characteristics of these women were described. Kaplan-Meier curve was used to analyze the cumulative prevalence of hypertension, and Cox regression was used to explore the influence of twin pregnancy on hypertension in women. Results The incidence of hypertension in the twin group was 8.8%(68/769), which was significantly higher than the singleton group(5.8%,45/781). Univariate Cox analysis revealed that twin pregnancy was a risk factor for hypertension(HR=1.57,95% CI:1.07-2.28). After adjusting for age, body mass index, education level, frequency of tea consumption, smoking, and alcohol consumption, twin pregnancy remained an independent risk factor for hypertension(adjusted HR=1.55,95% CI:1.06-2.27). Conclusion Twin pregnancy is an independent risk factor for hypertension in women. Risk management of long-term hypertension in women with twin pregnancy should be strengthened.
Key words
twin pregnancy /
women /
hypertension /
risk factor
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