Abstract:Objective To characterize HPV genotype profile of cervical intraepithelial neoplasia and cervical cancer. Methods From a population of 31 040 outpatients in Maternal and child care hospital of Guangdong Province, patients with high-risk HPV type positive underwent cytology examination. HPV positive and/or cytology ≥ ASCUS cases were recalled for colposcopic examination and multi-point biopsy if necessary. The diagnosis was defined with histopathology. Results Histology revealed CINⅠ with single type of HPV in 484 women, CINⅡ and CINⅢ in 252, cervical squamous cell carcinoma in 66, and cervical adenocarcinoma in 5 women. HPV52 was the most common type, with a detection rate of 5.4% (1 685/31 040) of all cases, followed by HPV 16, 58, 68, 18, 39, 33, 31, 56, 59, 51, 45, and 35. HPV52 as the single infection was the most common genotype in CINⅠ, with a detection rate of 21.7% (105/484). HPV16 was the main pathogenic genotype in CINⅡ-Ⅲ and cervical squamous cell carcinoma, being detected in 40.5% (102/252) and 71.2% (47/66), respectively. HPV18 was detected in 80% of cervical adenocarcinoma. All 21 types of HPV were risk factors for CINⅠ with HPV42 (OR=6.98, 95%CI: 1.17-41.8) having the highest risk. HPV16 (OR=7.09, 95%CI: 5.65-8.90) had the highest risk for CINⅡ-Ⅲ, followed by HPV 33, 58, 31, 18, 45, and 52. However, HPV59, 6, and 42 were not risk factors for CINⅡ-Ⅲ. HPV16 (OR=22.69, 95%CI: 15.92-32.34) had the highest risk for cervical cancer, followed by HPV 18, 58, 31, 59, 33, and 46. Conclusion HPV52 is the most common genotype, but not the type with the highest risk. HPV16, 58, 18, and 33 appeare to have higher oncogenic potential than other genotypes.
刘婷艳, 毛玲芝, 孙小丽, 李屹, 罗喜平. 不同HPV基因亚型单纯性感染与宫颈病变的关系[J]. 中国生育健康杂志, 2015, 26(3): 211-215.
LIU Tingyan, MAO Lingzhi, SUN Xiaoli, LI Yi, LUO Xiping. HPV genotype distribution in cervical intraepithelial neoplasia and cervical cancer. Chinese Journal of Reproductive Health, 2015, 26(3): 211-215.
1 Soerjomataram I,Lortet-Tieulent J,Parkin DM,et al.Global burden of cancer in 2008:a systematic analysis of disability-adjusted life-years in 12 world regions.Lancet,2012,380:1840-1850. 2 zur Hausen H.Human papillomavirus & cervical cancer.Indian J Med Res,2009,130:209. 3 Petry KU.HPV and cervical cancer.Scandinavian Journal of Clinical & Laboratory Investigation,2014,74:59-62. 4 Franco EL,Cuzick J.Cervical cancer screening following prophylactic human papillomavirus Vaccination.Vaccine,2008,26:A16-23. 5 de Sanjose S,Quint WG,Alemany L,et al.Human papillomavirus genotype attribution in invasive cervical cancer:a retrospective cross-sectional worldwide study.Lancet Oncol,2010,11:1048-1156. 6 WHO/ICO Information Centre on HPV and Cervical Cancer.HPV and cervical cancer in the 2007 report.Vaccine,2007,25:C1-230. 7 Pista A,Oliveira A,Verdasca N,et al.Single and multiple human papillomavirus infections in cervical abnormalities in Portuguese women.Clin Microbiol Infect,2011,17:941-946. 8 Price GJ,McCluggage WG,Morrison MML,et al.Computerized diagnostic decision support system for the classification of preinvasive cervical squamous lesions.Hum Pathol,2003,34:1193-1203. 9 Smith JS,Lindsay L,Hoots B,et al.Humanpapillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions:a meta-analysis update.Int J Cancer,2007,121:621-632. 10 Wentzensen N,Schiffman M,Dunn T,et al.Multiple humanpapillomavirus genotype infections in cervical cancer progression in the study tounderstand cervical cancer early endpoints and determinants.Int J Cancer,2009,125:2151-2158. 11 Castle PE,Rodriguez AC,Burk RD,et al.Shortterm persistence of human papillomavirus and risk of cervical precancer and cancer:population based cohort study.BMJ,2009,339:b2569. 12 Sandri MT,Riggio D,Salvatici M,et al.Typing of human papillomavirus in women with cervical lesions:prevalence and distribution of different genotypes.J Med Virol,2009,81:271-277. 13 Arbyn M,Kyrgiou M,Simoens C,et al.Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia:meta-analysis.BMJ,2008,337:a1284.