1 谭湘芳,张俊芳,陈鹄,等.血清Ghrelin 水平与多囊卵巢综合征胰岛素抵抗的相关性研究.现代预防医学,2013,40:3827-3832. 2 Kojima M,Hosoda H,Date Y,et al.Ghrelin is a growth-hormone-releasing acylated peptide from stomach.Nature,1999,40:656-660. 3 王楠,刘志敏.生长激素促释放剂受体配体的研究进展.生物技术通讯,2005,16:320-322. 4 Hosda H,Kojima M,Matasuo H,et al.Ghrelin and Desacyl Ghrelin:Two Major Forms of Rat Ghrelin Peptide in Gastrointestinal Tissue.Biochem Biophys Res Commun,2000,279:909-913 5 Aydin S.Proposal for the abbreviation of ghrelin-the appetite hormone.Horm Res,2006,66:206. 6 Aakawa A,Inui A,Fujimiya M,et al.Stomach Regulates Energy Balance Via Acylated Ghrelin and Desacyl Ghrelin.Gut,2005,54:18-24. 7 Gasco V,Beccuti G,Marotta F,et al.Endocrine and metabolic actions of ghrelin.Endocr Dev,2010,17:86-95. 8 裴晓萌,艾华.Ghrelin与摄食和肥胖的关系.卫生研究,2007,36:124-127. 9 Tschop M,Smiley DL,Heiman ML.Ghrelin induces adiposity in ordents.Nature,2000,407:908-913.. 10 Avart E,Di Vito L,Broglio F,et al.Preliminary evidence that Ghrelin,the natural GH secretagogue (GHS)—receptor ligand,stronggly stimulates GH secretion in humans.J Endocrinol Invest,2000,23:493-495. 11 Wren AM,Seal LJ,Cohen MA,et al.Ghrelin enhances appetide and increaces food intake in human.J Clin Endocrinol Metab,2001,86:5992. 12 Blom WA,Stafleu A,de Graaf C,et al.Ghrelin response to carbohydrate enriched breakfast is related to insulin.Am J Clin Nutr,2005,81:367-375. 13 杜鹃,王长江.多囊卵巢综合征患者空腹血清Ghrelin水平变化及相关因素分析.安徽医科大学学报,2013,48:178-181. 14 Mitkov M,Pehlivanov B,Orbetzova M.Serun ghrelin level in women with polycystic ovary syndrome and its relationship with endocrine and metabolic parameters.Gynecol Endocrinol,2008,24:625-630. 15 汪军,满君.脑肠肽(Ghrelin)与肥胖的关系及运动对其影响.The Relation between Ghrelin and Obesity and Effects of Exercise on Ghrelin.中国体育科技,2006,42:81-83. 16 程璐,万晓晨.超重肥胖与正常体重人群的促生长激素释放激素、胰高血糖素样肽1、瘦素、脂联素的研究.全科医学临床与教育,2013,11:552-554. 17 Katsuki A,Urakawa H,Gabazza EC,et al.Circulating levels of active ghrelin is associated with abdominal adiposity,hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus.Eur J Endocrinol,2004,151:573-577. 18 Kim MS,Yoon CY,Jang PG,et al.The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes.Mol Endocrinol,2004,18:2291-2301. 19 徐琳,陈子江.血清促生长激素释放激素受体配体与多囊卵巢综合征的相关性分析.实用妇产科杂志,2010,26:584-587. 20 Ferrero S,Anserini P,Remorgida V,et al.Total and active ghrelin levels in women with ploycystic ovary syndrome.Hum Reprod,2006,21:565. 21 Was′ko R,Komarowska H,Warenik-Szymankiewicz A,et al.Elevated ghrelin plasma levels in patients with polycystic ovary syndrome.Horm Metab Res,2004,36:170-173. 22 Nagaya N,Uematsu M,Kojima M,et al.Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure.Circulation,2001,104:1430-1435. 23 Di Vito L,Broglio F,Benso A,et al.The GH-releasing effect of ghrelin,a natural GH secretagogue,is only blunted by the infusion of exogenous somatostatin in humans.Clin Endocrinol (Oxf),2002,56:643-648. 24 Bowers CY.Unnatural growth hormone-releasing peptide begets natural ghrelin.J Clin Endocrinol Metab,2001,86:1464-1469. 25 刘锦霞,冷雯.多囊卵巢综合征患者外周血生长激素水平测定.生殖医学杂志,1994,3:150-152. 26 Pagotoo U,Gamnineri A,Vicennat V,et al.Plasma ghrelin,obesity,and the polycystic ovary syndrome:correlation with insulin resistance and androgen levels.J Clin Endocrinol Metab,2002,87:5625-5629. 27 Prado CL,Pugh-Bernard AE,Elghazi L,et al.Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.Proc Natl Acad Sci U S A,2004,101:2924-2929. 28 Mc Laughlin T,Abbasi F,Lamendola C,et al.Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls.J Clin Endocrinol Metab,2004,89:1630-1635. 29 Adeghate E,Ponery AS.Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats.J Neuroendocrinol,2002,14:555-560. 30 Reimer MK,Pacini G,Ahrén B.Dose-dependent inhibition by ghrelin of insulin secretion in the mouse.Endocrinology,2003,144:916-921. 31 Erdmann J,Lippl F,Wagenpfeil S,et al.Differential association of basal and postprandial plasma ghrelin with leptin,insulin,and type 2 diabetes.Diabetes,2005,54:1371-1378. 32 Xu L,Qu Z,Guo F,et al.Effects of ghrelin on gastric distention sensitive neurons in the arcuate nucleus of hypothalamus and gastric motility in diabetic rats.Peptides,2013,48:137-146. 33 张彦春,宋伟奇,等.多囊卵巢综合征患者血清Ghrelin水平测定及其意义.山东医药,2012,52:55-57. 34 班碧秀,肖常青.Ghrelin与胰岛素抵抗关系的研究进展.内科,2008,3:886-889.
