Abstract:Objective To explore the clinical value of activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis. Methods One hundred and thirty-nine patients with endometriosis were divided into three groups: peritoneal endometriosis (n=28), ovarian endometrioma (n=61), and deep infiltrating endometriosis (n=50). Seventy-five health women were included as the control group. Peripheral vein blood samples were collected for activin A and follistatin assessment by enzyme immunoassay kits. Results The ovarian endometrioma group [(0.22±0.01)ng/ml] had serum activin A levels significantly higher than healthy controls [(0.17±0.01)ng/ml]. Serum follistatin levels of all patients with endometriosis did not differ from healthy controls. However, follistatin levels in the endometrioma group [(2.24±0.42)ng/ml] were higher than that in the deep endometriosis group [(1.50±0.17)ng/ml]. The area under the receiver-operating characteristic (ROC) curve of activin A was 0.700 (95% CI: 0.605-0.794), while that of follistatin was 0.620 (95% CI: 0.51-0.73) for the diagnosis of ovarian endometrioma. The combination of the two markers did not improve diagnostic accuracy. Conclusion The present study demonstrated that serum activin A and follistatin are not significantly altered in peritoneal or deepinfiltrating endometriosis and have limited diagnostic accuracy in the diagnosis of ovarian endometrioma.
徐小艳, 洛若愚, 邢辉. 激活素A和卵泡抑素在子宫内膜异位症中的诊断价值[J]. 中国生育健康杂志, 2015, 26(2): 119-122.
XU Xiaoyan, LUO Ruoyu XING Hui. Diagnostic value of serum activin A and follistatin levels indifferent types of endometriosis. Chinese Journal of Reproductive Health, 2015, 26(2): 119-122.
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