Abstract：Objective To evaluate the clinical implications of serum plasminogen activator detection for neonatal asphyxia assessment, and to provide a new method for the clinical diagnosis of neonatal asphyxia. Methods Sixty-four cases of full-term neonates with asphyxia were selected in the Neonatology Department of our hospital during January 2012 and June 2013, and 20 cases of healthy full-term newborns were selected as controls over the same period. Serum tissue plasminogen activator (t-PA) and plasminogen activator inhibitor -1 (PAI-1) levels were detected by enzyme-linked immunosorbent assay. Differences in serum t-PA and PAI-1 levels between the neonatal asphyxia and control groups were examined, and correlations between the two markers and Apgar score were analyzed. Results Serum t-PA and PAI-1 levels of the mild asphyxia group, severe asphyxia group, and the control group were statistically significant different. The mild asphyxia group had significantly higher levels of serum t-PA and PAI-1 than the control group, and the severe asphyxia group had higher levels of the two markers than the mild asphyxia group and the control group. Negative correlations between serum t-PA and PAI-1 levels with Apgar score were observed (r1=-0.587 and r2=-0.407, respectively). Conclusion Serum t-PA and PAI-1 expression levels may be used as indicators for neonatal asphyxia assessment.
雷立容, 丘惠娴, 王晶, 曾淑娟, 杨皓. 血清纤溶酶原激活物诊断新生儿窒息的临床意义[J]. 中国生育健康杂志, 2015, 26(2): 136-138.
LEI Lirong, QIU Huixian, WANG Jing, ZENG Shujuan, YANG Hao. Clinical implications of serum plasminogen activator detection for the diagnosis of neonatal asphyxia. Chinese Journal of Reproductive Health, 2015, 26(2): 136-138.
