北京地区母体血清多环芳烃水平与自发性早产发生风险的关联性

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摘要目的探究母体血多环芳烃(PAHs)水平与自发性早产发生风险的关系。方法采用病例对照设计,共募集298名孕妇,包括99名为自发性早产(早产组),199名为足月分娩(对照组)。从医院电子病历系统采集孕妇的基本资料,分析孕妇基本资料;采集孕妇静脉血,用气相色谱-质谱联用仪定量血中15种PAHs浓度,比较两组的差异。结果血浆总PAHs(ΣPAHs)浓度为1 508 (577~2 633) ng/g脂肪,北京市城区孕妇孕中、晚期血PAHs浓度总体处于中等水平。早产组ΣPAHs为1 647 (578~2 951) ng/g脂肪,对照组为ΣPAHs为1 502(575~2 425) ng/g脂肪。除苯并(a)蒽外,北京市城区孕妇血浆中其他14种PAHs浓度水平在不同孕妇人群中分布无差异。结论未发现较高水平的孕中、晚期母体血PAHs显著增加自发性早产的风险。

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	陈小兰
	刘晓红^*
	霍文华
	刘念
	王斌
	李智文
	任爱国

关键词 ：多环芳烃, 自发性早产, 孕妇, 病例对照研究, 北京

Abstract：Objective To study the association between the level of polycyclic aromatic hydrocarbons (PAHs) in maternal plasma and the risk of spontaneous preterm birth.Methods We conducted a case-control study by recruiting a total of 298 pregnant women, including 99 women with spontaneous preterm birth and 199 women with the full term delivery. Demographic characteristics of those women were collected from computer-based patient record system. Concentrations of 15 US Environmental Protection Agency priority-controlled PAHs in the plasma samples were measured by gas chromatography-mass spectrometer.Results The median and interquartile range of ΣPAHs (the sum of 15 PAHs) was 1 508 (577-2 633) ng/g fat, while that of the case group was 1647 (578-2 951) ng/g fat and the control group was 1 502 (575-2 425) ng/g fat. Except for benzo(a)anthracene, no statistically significant differences between the two groups for the other 14 PAHs were observed between the case and control groups.Conclusion We didn't observe an association between the level of PAHs in plasma of pregnant women during the second and third trimester and during the third trimester with the risk of spontaneous preterm birth.

Key words： Polycyclic aromatic hydrocarbons Spontaneous preterm birth Pregnant women Case-control study Beijing

收稿日期: 2016-10-24

基金资助:国家自然科学基金(41401583和41371466);北京市海淀区支持核心区自主创新和产业发展专项资金(S2013009)

通讯作者: 王斌(binwangpku@foxmail.com)

引用本文:

陈小兰,刘晓红^*,霍文华,刘念,王斌,李智文,任爱国. 北京地区母体血清多环芳烃水平与自发性早产发生风险的关联性[J]. 中国生育健康杂志, 2017, 28(1): 1-5.
CHEN Xiaolan, LIU Xiaohong, HUO Wenhua, LIU Nian, WANG Bin, LI Zhiwen, REN Aiguo. Association of polycyclic aromatic hydrocarbons in maternal plasma with risk of spontaneous preterm birth. Chinese Journal of Reproductive Health, 2017, 28(1): 1-5.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2017/V28/I1/1

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