甲基泼尼松龙冲击治疗儿童肾脏疾病短期不良反应的临床观察

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摘要目的探讨甲基泼尼松龙冲击治疗多种儿童肾脏疾病的短期不良反应。方法采用前瞻性研究设计,以本院2014年1月—2015年12月行甲基泼尼松龙冲击治疗的肾脏疾病患儿,符合排除和纳入条件的46例为研究对象,观察甲基泼尼松龙冲击治疗的短期不良反应。结果冲击治疗前患儿均无感染和消化道不适。冲击后呼吸道感染4例(4/46,8.7%),其中上呼吸道感染2例,支气管炎2例,均为细菌感染;消化道轻微不适、食欲欠佳8例(8/46,17.4%),较治疗前升高,差异有统计学意义;所有患儿治疗过程中均无明确精神症状、心慌、乏力,无头晕、眼华、视物模糊,无恶心、呕吐及腹泻等表现,心电监测未发现心律失常。冲击治疗后平均双眼眼压、血压、体重均较冲击前增高,ALT一过性异常率(13.0%)和尿糖阳性率(13.0%)均明显高于冲击前,Scr异常率低于冲击前,差异均有统计学意义。冲击治疗后血常规白细胞总数、中性粒细胞百分比明显高于治疗前,差异有统计学意义有。结论甲基泼尼松龙冲击治疗在儿童肾脏疾病中应用相对安全,主要短期不良反应为体重增加、血压升高、眼压升高、感染和一过性肝功能异常。

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	张宏文
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关键词 ：甲基泼尼松龙, 冲击治疗, 肾脏疾病, 不良反应

收稿日期: 2016-09-07

通讯作者: 姚勇(yaoyong3238@126.com)

引用本文:

张宏文,李春珍,朱松柏,刘晓宇,姚勇. 甲基泼尼松龙冲击治疗儿童肾脏疾病短期不良反应的临床观察[J]. 中国生育健康杂志, 2017, 28(1): 55-57.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2017/V28/I1/55

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