Abstract：Objective To investigate the effect and the adverse events of synchronous exchange transfusion in treating severe hyperbilirubinemia of neonates.Methods A total of 400 newborns with severe hyperbilirubinemia were treated with automated homochronous arteria-vein exchange transfusion. Changes in blood cell counts, bilirubin, biochemistry items and adverse reactions were compared before and after therapy.Results The differences of serum total bilirubin and indirect bilirubin, hemoglobin, platelet and potassium, pH value, and BE value were statistically significant between before and after the exchange transfusion. Adverse reactions were observed for thrombocytopenia (25.8 %), hypokalemia (23.8 %), metabolic acidosis (17.8 %), and hyperglycemia (11.0 %).Conclusion Synchronous exchange transfusion has the advantage of obvious curative effect, but close attention needs to be paid to adverse reactions. Indications for the change should be followed; close monitoring of postoperative routine blood and the change of blood biochemical and electrolyte is crucial.
李翠莲,李杨芳,刘玲,尹丽娟. 换血治疗新生儿严重高胆红素血症400例[J]. 中国生育健康杂志, 2014, 25(1): 30-32.
LI Cuilian, LI Yangfang, LIU Ling, YIN Lijuan. Exchange transfusion treatment for severe hyperbilirubinemia: Analysis of 400 cases. Chinese Journal of Reproductive Health, 2014, 25(1): 30-32.
