宫腔灌注基因重组人绒毛膜促性腺激素联合静脉注射阿托西班在反复着床失败冻融周期囊胚移植中的临床效果

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摘要目的探讨胚胎反复着床失败(RIF)后冻融周期囊胚移植(FET)时行宫腔内灌注基因重组人绒毛膜促性腺激素(rhCG)并联合静脉注射缩宫素受体拮抗剂阿托西班对妊娠结局的影响。方法回顾性分析2014年6月—2016年6月在湖北省妇幼保健院生殖医学中心胚胎反复着床失败,再次行冻融胚胎移植(TET)囊胚的369例患者的临床资料,根据FET日是否使用rhCG及阿托西班分为三组,A组155例单独使用阿托西班,B组32例联合使用rhCG和阿托西班,C组182例作为对照组,未使用rhCG及阿托西班。分析比较各组间的临床妊娠率、胚胎着床率、多胎妊娠率、自然流产率及异位妊娠率。结果 A组临床妊娠率(67.1%)、胚胎着床率(48.2%)和B组临床妊娠率(62.5%)、胚胎着床率(46.7%)均显著高于对照组(依次为41.2%、32.1%),A、B组分别与对照组间差异有统计学意义,A组的临床妊娠率和胚胎着床率亦稍高于B组,但A、B两组差异并无统计学意义;A组自然流产率(9.6%)、多胎妊娠率(42.3%)和异位妊娠率(1.9%)均稍高于B组(5%、20%、0)和对照组(8%、28%、1.3%),但三组间差异均无统计学意义。结论 RIF患者FET日在囊胚移植前给予阿托西班和宫腔内灌注rhCG预处理可明显改善临床妊娠结局。

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	刘杰
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关键词 ：阿托西班, 宫腔灌注, 反复种植失败, 冻融胚胎移植, 临床妊娠率

收稿日期: 2016-11-18

通讯作者: 刘杰(liujielj365@126.com)

引用本文:

刘杰,郑洁,雷亚兰,夏敏,孙虹. 宫腔灌注基因重组人绒毛膜促性腺激素联合静脉注射阿托西班在反复着床失败冻融周期囊胚移植中的临床效果[J]. 中国生育健康杂志, 2017, 28(4): 378-381.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2017/V28/I4/378

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