1 Delabaere A,Huchon C,Deffieux X,et al.Epidemiology of loss pregnancy.J Gynecol Obstet Biol Reprod (Paris),2014,43:764-775. 2 Alijotas-Reig J,Llurba E,Gris JM,et al.Potentiating maternal immune tolerance in pregnancy:a new challenging role for regulatory T cells.Placenta,2014,35:241-248. 3 Solt LA,Kumar N,Nuhant P,et al.Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.Nature,2011,472:491-494. 4 Basu R,Hatton RD,Weaver CT,et al.The Th17 family:flexibility follows function.Immunol Rev,2013,252:89-103. 5 Nakashima A,Ito M,Yoneda S,et al.Circulating and decidual Th17 cell levels in healthy pregnancy.Am J Reprod Immunol,2010,63:104-109. 6 Wang WJ,Hao CF,Yi Lin,et al.Increased prevalence of T helper 17(Th17)cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients.J Reprod Immunol,2010,84:64-70. 7 Saito S,Nakashima A,Shima T,et al.Th1/Th2 /Th17 and regulatory T-cell paradigm in pregnancy.Am J Reprod Immunol,2010,63:601-610. 8 Nakashima A,Ito M,Shima T,et al.Accumulation of IL-17-positive cells in decidua of inevitable abortion case.Am J Reprod Immunol,2010,64:4-11. 9 Clark DA,Chaouat G.Regulatory T cells and reproduction:how do they do it.J Reprod Immunol,2012,96:1-7. 10 La Rocca C,Carbone F,Longobardi S,et al.The immunology of pregnancy:Regulatory T cells control maternal immune tolerance toward the fetus.Immunol Lett,2014,162:41-48.11 Dimova T,Nagaeva O,Stenqvist AC,et al.Maternal Foxp3 expressing CD4+CD25+ and CD4+CD25+-reguatory T-cell populations are enriched in human early normal preganncy decidua:a phentypic study of paired decidual and peripheral blood samples.Am J Reprod Immunol,2011,661:44-56. 12 Liu YS,Wu L,Tong XH,et al.Study on the relationship between Th17 cells and explained recurrent spontaneous abortion.Am J Reprod Immunol,2011,65:503-511. 13 Miyara M,Sakaguchi S.Human FoxP3(+)CD4(+)regulatory T cells:their knowns and unknowns.Immunol Cell Biol,2011,89:346-351. 14 Mjosberg J,Berg G,Jenmalm MC,et al.Foxp3 regulatory T cells and T helper 1,T helper 2,and T helper 17 cells in human early pregnancy decidua.Biology of Reproduction,2010,82:698-705. 15 Wang WJ,Hao CF,Qu QL,et al.The deregulation of regulatory T cells on interleukin -17 -producing T helper cells in patients with unexplained early recurrent miscarriage.Hum Reprod,2010,25:2591-2596. 16 Nasrin S,Marjan G,Vajihe O,et al.Variations in T-helper 17 and Regulatory T Cells during The Menstrual Cycle in Peripheral Blood of Women with Recurrent Spontaneous Abortion.Fertil Steril,2014,8:59-66. 17 Saifi B,Rezaee SA,Tajik N,et al.Th17 cells and related cytokines in unexplained recurrent spontaneous miscarriage at the implantation window.Reprod Biomed Online,2014,29:481-489. 18 Winger EE,Reed JL.Low circulating CD4(+)CD25(+) Foxp3(+)T regulatory cell levels predict miscarriage risk in newly pregnant women with a history of failure.Am J Reprod Immunol,2011,66:320-328. 19 Wu L,Luo LH,Zhang YX,et al.Alteration of Th17 and Treg cells in patients with unexplained recurrent spontaneous abortion before and after lymphocyte immunization therapy.Reprod Biol Endocrinol,2014,12:74. 20 Bozic Antic I,Macut D,Popovic B,et al.Recurrent spontaneous abortions,Hashimoto thyroiditis and alopecia totalis:response to anticoagulation and intravenous immunoglobulin therapy.Gynecol Endocrinol,2014,30:100-102. 21 Schumacher,ABrachwitz N,Sohr S,et al.Human chorionic gonadotropin attracts regulatory T cells into the fetal -maternal interface during early human pregnancy.J Immunol,2009,182:5488-5497. 22 Xiong YH,Yuan Z,He L,et al.Effects of estrogen on CD4(+) CD25(+) regulatory T cell in peripheral blood during pregnancy.Asian Pac J Trop Med,2013,6:748-752. 23 Würfel W,Santjohanser C,Hirv K,et al.High pregnancy rates with administration of granulocyte colony-stimulating factor in ART-patients with repetitive implantation failure and lacking killer-cell immunglobulin-like receptors.Hum Reprod,2010,5:2151-2152.