二甲双胍在多囊卵巢综合征应用中的研究进展

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摘要多囊卵巢综合征(PCOS)是一种内分泌紊乱性疾病,在育龄妇女中常见,是无排卵性不孕症中的常见原因,临床以高雄激素血症,排卵障碍或无排卵,卵巢多囊样改变为特征,常伴有胰岛素抵抗和肥胖。二甲双胍为胰岛素增敏剂,主要用于2型糖尿病患者的治疗。近20年来,二甲双胍在多囊卵巢综合征患者中的应用效果得到了越来越多的学者的关注。二甲双胍应用于多囊卵巢综合征效果显著,具有重要的临床意义。现对国内外研究成果做以综述,为临床治疗提供依据。

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	徐丽君
	杜伯涛

关键词 ：二甲双胍, 多囊卵巢综合征, 胰岛素抵抗, 高雄激素血症

通讯作者: 杜伯涛(Botaodu34@sina.com)

引用本文:

徐丽君, 杜伯涛. 二甲双胍在多囊卵巢综合征应用中的研究进展[J]. 中国生育健康杂志, 2016, 27(3): 298-300.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2016/V27/I3/298

1 Kubota T.Update in polycystic ovary syndrome:new criteria of diagnosis and treatment in Japan.Reprod Med Biol,2013,12:71-77.
2 Palomba S,Falbo A,Russo T,et al.Pregnancy in women with polycystic ovary syndrome:the effect of different phenotypes and features on obstetric and neonatal outcome .Fertil Steril,2010,94:1805-1811.
3 Panidis D,Tziomalos K,Papadakis E,et al.Infertility treatment in polycystic ovary syndrome:lifestyle interventions,medications and surgery.Front Horm Res,2013,40:128-141.
4 Sirmans SM,Pate KA.Epidemiology diagnosis,and management of polycystic ovary syndrome.Clin Epidemiol,2013,6:1-13.
5 Yavuz Taslipinar M,Kilic N,Bayraktar,et al.Endothelial dysfunction and insulin resistance in young women with polycystic ovarian syndrome.Turk J Med Sci,2014,44:787-791.
6 Makled AK,EI Sherbiny M,Elkabarity R.Assessment of ovarian stromal blood flow after metformin treatment in women with polycystic ovary syndrome.Arch Gynecol Obstet,2014,289:883-891.
7 Sivalingam VN,Myers J,Nicholas S,et al.Metformin in reproductive health,pregnancy and gynaecological cancer:established and emerging indications.Hum Reprod Update,2014,20:853-868.
8 Hwang KR,Choi YM,Kim JJ,et al.Effects of insulin-sensitizing agents and insulin resistance in women with polycystic ovary syndrome.Clin Exp Reprod Med,2013 40:100-105.
9 唐婷婷.二甲双胍与达英-35治疗多囊卵巢综合征的临床疗效对比分析.中国实用医药,2014,9:9-10.
10 Chung JP,Yiu AK,Chung TK,et al.A randomized crossover study of medroxyprogesterone acetate and Diane-35 in adolescent girls with polycystic ovarian syndrome.J Pediatr Adolesc Gynecol,2014,27:166-171.
11 Jing Z,Liang-Zhi X,Tai-Xiang W,et al.The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome:an updated systematic review.Gynecol Endocrinol,2008,24:590-600.
12 Kurzthaler,Hadziomerovic-Pekic D,Wildt L,et al.Metformin induces a prompt decrease in LH-stimulated testosterone in women with PCOS independent of its insulin-sensitizing effects.Reproductive Biology and Endocrinology,2014 ,12:98.
13 Nawrocka-Rutkowska J,Ciec′wie S,Marciniak A,et al.Insulin resistance assessment in patients with polycystic ovary syndrome using different diagnostic criteria--impact of metformin treatment.Ann Aqric Environ Med,2013,20:528-532.
14 Ayaz A,Alwan Y,Farooq.Efficacy of combined metformin-clomiphene citrate in comparison with clomiphene citrate alone in infertile women with polycystic ovarian syndrome.Med Life,2013,6:199-201.
15 Raffone E,Rizzo P,Benedetto V.Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women.Gynecol Endocrinol,2010,26:275-280.
16 Palomba S,FalboA,La Sala GB.Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome:a systematic review with meta-analysis of randomized controlled trials.Reprod Biol Endocrinol,2014,12:3.
17 Tso LO,Costello MF,Albuquerque LE.Metfoemin treatment before and during IVF or ICSI in women with polycystic ovary syndrome.Cochrane Database Syst Rev,2014,11:CD006105.
18 Lopes IM,Baracat MC,Baracat EC,et al.Endometrium in women with polycystic ovary syndrome during the window of implantation.Rev Assoc Med Bras,2011,57:702-709.
19 叶飞雪.盐酸二甲双胍治疗多囊卵巢综合征对排卵和子宫内膜容受性的影响.中国现代医药杂志,2014,16:36-38.
20 Christianson MS,Wu H,Zhao Y,et al.Metformin use in patients undergoing in vitro fertilization treatment:results of a worldwide web-based survey.J Assist Reprod Genet,2015,32:401-406.
21 Diamanti- Kandarakis E,Christakou CD,Kandaraki E,et al.Metformin:an old medication of new fashion:evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome.Eur J Endocrinol,2010,162:193-212.
22 贾双征.妊娠期应用二甲双胍对多囊卵巢综合症患者影响的meta分析.山东大学,2010,30:100-104.
23 Bertoldo MJ,Faure M,Dupont J,et al.Impact of metformin on reproductive tissues:an overview from gametogenesis to gestation.Ann Transl Med,2014,2:55.
24 Michael J.Bertoldo,Melanie Faure,Joelle Dupont,etal.Impact of metformin on reproductive tissues:an overview from gametogenesis to gestation.Annals of Translational Medicine,2014,2:55.
25 Rizzo M,Berueis K,Carmina E,et al.How should we manage atherogenic dyslipidemia in women with polycystic ovary syndrome.Am J Obstet Gynecol,2008,198:28-35.
26 Carroll DG,Kelley KW.Review of metformin and glyburide in the management of gestational diabetes.Pharm Pract,2014,12:528.
27 Milewicz A.Metformin for polycystic ovary syndrome.Endokrynol Pol,2013,64:409-414.
28 Li X,Guo YR,Lin JF,etal.Combination of Diane-35 and Metformin to Treat Early Endometrial Carcinoma in PCOS Women with Insulin Resistance.Cancer,2014,5:173-181.
29 刘伟.从PCOS的不同发病机制看防治观念的进展.药物与临床,2014,11:29-31.

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