Abstract：Objective To investigate the efficacy and safety of cranial electrotherapy stimulation (CES) in the treatment of mild to moderate postpartum depression. Methods Thirty-six patients with mild to moderate postpartum depression were randomly divided into two groups:CES treatment group and control group, 18 cases in each group. The experimental group received CES treatment for 20 minutes five days a week for 3 weeks, while the control group opened the device to numb the patient′s earlobe, and then closed it. Hamilton Depression Scale (HAMD-17) and CGI-SI were used to evaluate the clinical efficacy before and after treatment, and adverse reactions were recorded during the intervention. Results There was no significant difference in general data between the two groups before treatment. There was significant difference in HAMD-17 and CGI-SI scores between the two groups after treatment (P<0.05). Covariance analysis showed that the improvement of depression in the treatment group was statistically significant, with significant differences between groups. There were no serious adverse reactions in both groups, and there was no significant difference between the two groups. Conclusion CES is effective and safe in the treatment of mild to moderate postpartum depression, which deserves further study.
1 Webster J,Nicholas C,Velacott C,et al.Quality of life and depression following childbirth:impact of social support.Midwifery,2011,27:745-749. 2 钱耀荣,晏晓颖.中国产后抑郁发生率的系统分析.中国实用护理杂志,2013,11:1-3. 3 Chen H,Chan Y R,Tan K H,et al.Depressive symptomatology in pregnancy - a Singaporean perspective.Soc Psych Psych Epid,2004,39:975-979. 4 Morrell CJ,Sutcliffe P,Booth A,et al.A systematic review,evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness,the cost-effectiveness,safety and acceptability of interventions to prevent postnatal depression.Health Technol Assess,2016,20:1-414. 5 Lanza DST,Wisner KL.Antidepressant medication use during breastfeeding.Clin Obstet Gynecol,2009,52:483-497. 6 Gilula MF,Kirsch DL.Cranial electrotherapy stimulation review:a safer alternative to psychopharmaceuticals in the treatment of depression.J Neuro Oncol,2005,9:7-26. 7 丁辉,陈林,邸晓兰.产后抑郁障碍防治指南的专家共识(基于产科和社区医生).中国妇产科临床杂志,2014,9:572-576. 8 谢光荣,沈其杰,张吉田,等.HAMILTON与CARROLL抑郁量表在正常人和抑郁症病人中的评定.中国神经精神疾病杂志,1984:346-349. 9 吴文源.临床疗效总评量表(CGI).上海精神医学,1984,10:76-77. 10 Pitt B."Atypical" depression following childbirth.Br J Psychiat,1968,114:1325-1335. 11 Pedersen CA,Johnson JL,Silva S,et al.Antenatal thyroid correlates of postpartum depression.Psychoneuroendocrino,2007,32:235-245. 12 张小勤.产后忧郁、产后抑郁患者雌二醇、孕酮和瘦素水平变化的研究.中国妇幼保健,2010,23:2787-2791. 13 古航,胡电,洪新如,等.产后抑郁症患者血浆孤啡肽及5-羟色胺水平变化的意义.中华妇产科杂志,2003,12:10-11. 14 Shagass C,Roemer RA,Straumanis JJ,et al.Combinations of evoked potential amplitude measurements in relation to psychiatric diagnosis.Biol Psychiat ,1985,20:701-722. 15 Smith RB.Microcurrent therapies:emerging theories of physiological information processing.NeuroRehabilitation,2002,17:3-7. 16 杨启辉.抑郁症经颅微电流治疗系统.华南理工大学,2012. 17 Shealy C,Cady R,Wilkie RG.Cerebrospinal fluid and plasma neurochemicals:Response to cranial electrical stimulation.J Neurol Orthop Med Surg,1998,18:94-97. 18 闫芬.CES微电流脑导入系统辅助治疗抑郁症的探讨.中国民康医学,2009,23:3020- 3022. 19 杨启辉,吴效明.经颅微电流刺激仪的设计及其对α脑电波作用的研究.医疗卫生装备,2011,21:12-13. 20 Schroeder M,Barr R.Quantitative analysis of the electroencephalogram during cranial electrotherapy stimulation.Clin Neurophysiol,2001,112:2075-2083. 21 Klawansky S,Yeung A,Berkey C,et al.Meta-analysis of randomized controlled trials of cranial electrostimulation.Efficacy in treating selected psychological and physiological conditions.J Nerv Ment Dis,1995,183:478-484. 22 Murphey C,Carter P,Price LR,et al.Psychological distress in healthy low-risk first-time mothers during the postpartum period:an exploratory study.Nurs Res Pract,2017,15:83-87. 23 Moreno-Duarte I,Morse LR,Alam M,et al.Targeted therapies using electrical and magnetic neural stimulation for the treatment of chronic pain in spinal cord injury.Neuroimage,2014,85:1003-1013.
