MicroRNA-182和microRNA-152在早期子宫内膜癌组织中的差异性表达

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摘要目的检测microRNA-182(miRNA-182)和microRNA-152(miRNA-152)在早期子宫内膜癌组织中的表达情况,探究二者与子宫内膜癌疾病演变的相关性。方法采集2018年3月至2018年8月河北大学附属医院收治的子宫内膜癌患者的肿瘤组织标本和因子宫肌瘤行全子宫切除术患者的正常内膜组织标本各40例。采用实时聚合酶链反应(real-time PCR)检测两组标本中miRNA-182和miRNA-152的表达。结果纳入研究的子宫内膜癌患者及子宫肌瘤患者年龄比较,差异无统计学意义(P>0.05)。miRNA-182在子宫内膜癌组和正常内膜组的表达水平分别为(1.5499 ±0.4808)和(0.7767±0.4072),miRNA-152在子宫内膜癌组和正常内膜组的表达水平分别为(0.5010±0.2363)和(0.9037±0.2304),差异均具有统计学意义(P<0.05)。结论 miRNA-152在早期子宫内膜癌组织中低表达,而miRNA-182高表达,提示二者分别作为抑癌基因和促癌基因参与子宫内膜癌疾病的发生和演变过程。miRNA-182和miRNA-152有可能作为十分重要的子宫内膜癌肿瘤生物学分子标记物用于疾病的筛查、早期诊断、判断预后及随访观察,同时未来有可能作为子宫内膜癌分子靶向治疗的药物应用于临床。

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关键词 ：早期子宫内膜癌, miRNA-182, miRNA-152, real-time PCR

收稿日期: 2019-11-26

通讯作者: 梁义娟(juandoctor@yeah.net)

引用本文:

曹双双, 陈世超, 解丹, 梁义娟. MicroRNA-182和microRNA-152在早期子宫内膜癌组织中的差异性表达[J]. 中国生育健康杂志, 2020, 31(3): 266-269.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2020/V31/I3/266

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