1 Parkin DM ,Bray F,Ferlay J ,et al.Global cancer statistics,2002. CA Cancer J Clin,2005,55:74 -108. 2 谢幸,苟文丽等.妇产科学.8版.北京:人民卫生出版社,2013:313. 3 刘麒薇,杨敏,童晓文,等.微小RNA与子宫内膜癌相关性的研究进展.国际妇产科学杂志,2014:401-404. 4 Lee RC,Feinbaum RL,Ambros V.The C.elegans heterochronic genes lin-4 encodes small mas with antisense complementarity to lin-14. Cell,1993,75:843-854. 5 李欣,李小青,黄士昂.microRNA表达谱与消化器官肿瘤的发生、诊断及治疗.世界华人消化杂志,2007,15:1241-1245. 6 Calin GA,Sevignani C,Dumitru CD,et al.Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.Proc Natl Acad Sci U.S.A,2004,101:2999-3004. 7 Widodo,Djati MS,Rifa'i M.Role of MicroRNAs in carcinogenesis that potential for biomarker of endometrial cancer.Ann Med Surg,2016,7:9-13. 8 Zhou Q,Huang SX,Zhang F,et al.MicroRNAs:A novel potential biomarker for diagnosis and therapy in patients with non-small cell lung cancer.Cell Prolif,2017,50:e12394. 9 张禹,杨宏英,姚宇峰,等.微小 RNA-214在宫颈癌中的研究进展.医学研究生学报,2017,30:104-107. 10 Stumpel DJ,Schotte D,Lange-Turenhout EA,et al.Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia:major matters at a micro scale.Leukemia,2011,25:429-439. 11 Huang J,Wang Y,Guo Y,et al.Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus–related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology,2010,52:60-70. 12 Lewis BP,Burge CB,Bartel DP.Conserved seed pairing,often flanked by adenosines,indicates that thousands of human genes are microRNA targets.Cell,2005,120:15-20. 13 Friedrich M,Pracht K,Mashreghi MF,et al.The role of the miR-148/-152 family in physiology and disease.Eur J Immunol,2017,47:2026-2038. 14 NCBI Resource Coordinators.Database Resources of the National Center for Biotechnology Information.Nucleic Acids Res,2017,45:12-17. 15 Liu X,Li J,Qin F,et al.miR-152 as a tumor suppressor microRNA:Target recognition and regulation in cancer.Oncol Lett,2016,11:3911-3916. 16 Ling C,Liu Y,Dan W,et al.MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling.J Exp Clin Cancer Res,2018,37:83. 17 Kim TH,Song JY,Park H,et al.miR-145,targeting high-mobility group A2,is a powerful predictor of patient outcome in ovarian carcinoma.Cancer Lett,2015,356:937-945. 18 Daugaard I,Knudsen A,Kjeldsen TE,et al.The association between miR-34 dysregulation and distant metastases formation in lung adenocarcinoma.Exp Mol Pathol,2017,102:484. 19 Xie D,Liang Y,Su Y.miR-152 inhibits proliferation of human endometrial cancer cells via inducing G2/M phase arrest by suppressing CDC25B expression.Biomed pharmacother,2018,99:299-305. 20 Zhou L,Chen J,Li Z,et al.Integrated Profiling of MicroRNAs and mRNAs:MicroRNAs Located on Xq27.3 Associate with Clear Cell Renal Cell Carcinoma.PLoS One,2010,5:e15224. 21 Ji W,Yang L,Yuan J,et al.MicroRNA-152 targets DNA methyltransferase 1 in NiS-transformed cells via a feedback mechanism.Carcinogenesis,2013,34:446-453. 22 Zhu C,Li J,Ding Q,et al.miR-152 controls migration and invasive potential by targeting TGFα in prostate cancer cell lines.Prostate,2013,73:1082-1089. 23 Köhler CU,Bryk O,Meier S,et al.Analyses in human urothelial cells identify methylation of miR-152,miR-200b and miR-10a genes as candidate bladder cancer biomarkers.Biochem Biophys Res Commun,2013,438:48-53. 24 Sanfiorenzo C,Ilie MI,Belaid A,et al.Two Panels of Plasma MicroRNAs as Non-Invasive Biomarkers for Prediction of recurrence in resectable NSCLC.PLoS One,2013,8:e54596. 25 Cheng Z,Ma R,Tan W,et al.MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2. Exp Mol Me,2014,46:e112. 26 Su Y,Wang Y,Zhou H,et al.MicroRNA-152 targets ADAM17 to suppress NSCLC progression.FEBS Lett,2014,588:1983-1988. 27 Qin W,Xie W,He Q,et al.MicroRNA-152 inhibits ovarian cancer cell proliferation and migration and may infer improved outcomes in ovarian cancer through targeting FOXP1. Exp Ther Med,2018,15:1672-1679. 28 Ge S,Wang D,Kong Q,et al.Function of miR-152 As a Tumor Suppressor in Human Breast Cancer By Targeting PIK3CA.Oncol Res,2017,25:1363-1371. 29 Wang XY,Wu MH,Liu F,et al.Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells.Mol Cell Biochem,2010,345:283-290. 30 Tang XL,Lin L,Song LN,et al.Hypoxia-inducible miR-152 suppresses the expression of WNT1 and ERBB3,and inhibits the proliferation of cervical cancer cells.Exp Biol Med (Maywood),2016,241:1429-1437. 31 Zheng X,Chopp M,Lu Y,et al.MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3. Cancer Lett,2013,329:146-154. 32 Mitamura T,Watari H,Wang L,et al.microRNA 31 functions as an endometrial cancer oncogene by suppressing Hippo tumor suppressor pathway.Mol Cancer,2014,13:97. 33 郭静,马晓欣.miRNA302b在子宫内膜癌中的表达及其与临床病理参数的关系.现代肿瘤医学,2017,25:123-126. 34 安琪,马晓欣.miRNA-302c在子宫内膜癌组织中的表达及其与临床病理资料的关系.现代肿瘤医学,2017,25:132-135. 35 Myatt SS ,Wang J ,Monteiro LJ ,et al.Definition of microRNAs That repressexpression of the tumor suppressor gene FOXO1 in endometrial cancer.Cancer Res,2010,70:367-377. 36 Tsuruta T,Kozaki K,Uesugi A,et al.miR-152 Is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer.Cancer Res,2011,71:6450-6462. 37 Xu Q,Jiang Y,Yin Y,et al.A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. J Mol Cell Biol,2013,5:3-13. 38 Youbo Z,Yuan DZ,Pan JL,et al.Effect of Progesterone-induced MicroRNA-152 on the Proliferation of Endometrial Epithelial Cells.Sichuan Da Xue Xue Bao Yi Xue Ban,2016,47:147-151. 39 Nie L,Zhao YB,Pan JL,et al.Progesterone-Induced miR-152 Inhibits the Proliferation of Endometrial Epithelial Cells by Downregulating WNT-1. Reprod Sci,2017,24:1444-1453. 40 Yang CH,Zhang XY,Zhou LN,et al.LncRNA SNHG8 participates in the development of endometrial carcinoma through regulating c-MET expression by miR-152. Eur Rev Med Pharmacol Sci,2018,22:1629-1637. 41 Bader AG .miR-34-a microRNA replacement therapy is headed to the clinic.Front Genet,2012,3:120.