新型冠状病毒感染与孕产妇不良妊娠结局关系的研究现状

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (719 KB) HTML (33 KB)
输出: BibTeX | EndNote (RIS)

摘要新型冠状病毒(简称“新冠病毒”)的传染性较强,已在全国范围内导致超8万人确诊感染,其中关于新冠病毒对孕产妇人群健康的影响被广泛关注,需要较为系统的综述报道。本文总结了目前有关新冠病毒对孕产妇妊娠结局影响的研究结果,结合既往其他冠状病毒对孕产妇影响的研究,探讨了新冠病毒感染对孕产妇不良妊娠结局的潜在影响。对于新冠病毒能否进行垂直传播,尚未证明或排除该可能性,但目前为止没有明确证据支持存在垂直传播。新冠病毒感染孕产妇及其胎儿的死亡率较低,但不良妊娠结局或孕期并发症率明显升高,包括早产、低出生体重、胎膜早破、胎儿窘迫等。因此,未来仍需要深入开展新冠病毒对生育健康的影响研究。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	李泽武
	巴哈白克·江吐鲁
	任梦圆
	贾晓倩
	陈俊熹
	兰场新
	鹿群
	庄丽丽
	刘倩
	李智文
	王斌
	叶荣伟

关键词 ：新型冠状病毒, SARS-CoV-2, 新冠肺炎, COVID-19, 孕产妇, 不良妊娠结局

收稿日期: 2020-04-13

基金资助:国家自然科学基金(41771527,81673177)

通讯作者: 李智文(lizw@bjmu.edu.cn);王斌(binwangpku@foxmail.com)

引用本文:

李泽武, 巴哈白克·江吐鲁, 任梦圆, 贾晓倩, 陈俊熹, 兰场新, 鹿群, 庄丽丽, 刘倩, 李智文, 王斌, 叶荣伟. 新型冠状病毒感染与孕产妇不良妊娠结局关系的研究现状[J]. 中国生育健康杂志, 2020, 31(3): 273-276.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2020/V31/I3/273

1 WHO.Naming the coronavirus disease (COVID-19) and the virus that causes it,2020,https://www.who.int/zh/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it.
2 The species severe acute respiratory syndrome-related coronavirus:classifying 2019-nCoV and naming it SARS-CoV-2.Nat Microbiol,2020,5:536-44.
3 Zhu H,Wang L,Fang C,et al.Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia.Transl Pediatr,2020,9:51-60.
4 Chen H,Guo J,Wang C,et al.Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women:a retrospective review of medical records.Lancet,2020,395:809-15.
5 陈烁,黄博,罗丹菊,等.新型冠状病毒感染孕妇三例临床特点及胎盘病理学分析[J/OL].中华病理学杂志,2020,49 (2020-03-02).http://rs.yiigle.com/yufabiao/1183280.htm.DOI:10.3760/cma.j.cn112151-20200225-00138.
6 张露,江燕,魏敏,et al.湖北地区新型冠状病毒肺炎流行期间孕妇的妊娠结局分析[网络预发表].中华妇产科杂志,2020,55:E009-E.doi:10.3760/cma.j.cn112141-20200218-00111.
7 Wang X,Zhou Z,Zhang J,et al.A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery [published online ahead of print,2020 Feb 28].Clin Infect Dis,2020,ciaa200:doi:10.1093/cid/ciaa200.
8 Li Y,Zhao R,Zheng S,et al.Lack of vertical transmission of severe acute respiratory syndrome coronavirus 2,China [published online ahead of print,2020 Jun 17].Emerg Infect Dis,2020,26:doi:10.3201/eid2606.200287.
9 Liu Y,Chen H,Tang K,et al.Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy [published online ahead of print,2020 Mar 4].J Infect,2020,S0163-4453:30109-2.doi:10.1016/j.jinf.2020.02.028.
10 Liu D,Li L,Wu X,et al.Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia:a preliminary analysis.AJR Am J Roentgenol,2020,18:1-6.
11 Lee D,Lee J,Kim E,et al.Emergency cesarean section on severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) confirmed patient.Korean J Anesthesiol,2020,doi:10.4097/kja.20116.
12 Iqbal S,Overcash R,Mokhtari N,et al.An uncomplicated delivery in a patient with COVID-19 in the United States.N Engl J Med,2020,doi:10.1056/NEJMc2007605.
13 Breslin N,Baptiste C,Miller R,et al.COVID-19 in pregnancy:early lessons.Am J Obstet Gynecol,2020,100111.doi:https://doi.org/10.1016/j.ajogmf.2020.100111.
14 Yu N,Li W,Kang Q,et al.Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan,China:a retrospective,single-centre,descriptive study.Lancet Infect Dis,2020.
15 Zambrano L,Fuentes-Barahona I,Bejarano-Torres D,et al.A pregnant woman with COVID-19 in Central America [Epub ahead of print].Travel Med Infect Dis,2020,101639.doi:10.1016/j.tmaid.2020.101639.
16 Chen S,Liao E,Cao D,et al.Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia [Epub ahead of print].J Med Virol,2020,doi:10.1002/jmv.25789.
17 Fan C,Lei D,Fang C,et al.Perinatal transmission of COVID-19 associated SARS-CoV-2:should we worry? [Epub ahead of print].Clin Infect Dis,2020,ciaa226:doi:10.1093/cid/ciaa226.
18 Li M,Chen L,Xiong C,et al.The ACE2 expression of maternal-fetal interface and fetal organs indicates potential risk of vertical transmission of SARS-COV-2.bioRxiv,2020,2020.02.27.967760.doi:10.1101/2020.02.27.967760.
19 Zheng Q,Duan T,Jin L.Single-cell RNA expression profiling of ACE2 and AXL in the human maternal-fetal interface.Reprod Dev Med,2020,web published 18-Feb-2020:doi:10.4103/2096-2924.278679.
20 Zeng H,Xu C,Fan J,et al.Antibodies in infants born to mothers with COVID-19 pneumonia.JAMA,2020,doi:10.1001/jama.2020.4861.
21 Dong L,Tian J,He S,et al.Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn.JAMA,2020,doi:10.1001/jama.2020.4621.
22 詹菁,刘倩,张雨竹,et al.新型冠状病毒2019-nCoV的一些初步认识.环境化学,2020,283-91.doi:10.7524/j.issn.0254-6108.2020021501.
23 国家卫健委医政医管局.新型冠状病毒肺炎诊疗方案(试行第七版),2020,http://www.nhc.gov.cn/yzygj/s7652m/202003/a31191442e29474b98bfed5579d5af95.shtml.
24 中华预防医学会新型冠状病毒肺炎防控专家组.新型冠状病毒肺炎流行病学特征的最新认识.中华流行病学杂志,2020,41:139-44.
25 中国疾病预防控制中心.2019新型冠状病毒疫情进展和风险评估,2020,http://www.chinacdc.cn/jkzt/crb/zl/szkb_11803/jszl_11811/202001/P020200128523354919292.pdf.
26 Yu N,Li W,Kang Q,et al.Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan,China:a retrospective,single-centre,descriptive study.Lancet Infect Dis,2020,doi:10.1016/s1473-3099(20)30176-6.
27 Qiao J.What are the risks of COVID-19 infection in pregnant women? Lancet,2020,395:760-2.
28 国家产科医疗质量管理和控制中心.新型冠状病毒肺炎孕产妇分娩期管理建议.中华妇产科杂志,2020,55:E007-E.doi:10.3760/cma.j.cn112141-20200224-00128.
29 中国疾病预防控制中心新型冠状病毒肺炎应急响应机制流行病学组.新型冠状病毒肺炎流行病学特征分析.中华流行病学杂志,2020,41:145-51.
30 Wong S,Chow K,Leung T,et al.Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome.Am J Obstet Gynecol,2004,191:292-7.
31 张建平,王蕴慧,陈雷宁,et al.妊娠中晚期合并重症急性呼吸综合征的临床分析.中华妇产科杂志,2003,38:516-20.
32 Ng P,Leung C,Chiu W,et al.SARS in newborns and children.Biol Neonate,2004,85:293-8.
33 Ng P,So K,Leung T,et al.Infection control for SARS in a tertiary neonatal centre.Arch Dis Child Fetal Neonatal Ed,2003,88:F405-9.
34 Park M,Kim H,Choi D,et al.Emergency cesarean section in an epidemic of the middle east respiratory syndrome:a case report.Korean J Anesthesiol,2016,69:287-91.
35 Malik A,El Masry K,Ravi M,et al.Middle east respiratory syndrome coronavirus during Pregnancy,Abu Dhabi,United Arab Emirates,2013.Emerg Infect Dis,2016,22:515-7.
36 Alfaraj S,Al-Tawfiq J,Altuwaijri T,et al.Middle east respiratory syndrome coronavirus in pediatrics:a report of seven cases from Saudi Arabia.Front Med,2019,13:126-30.