1 Ferlay J,Autier P,Boniol M,et al.Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol,2007,18:581-592. 2 Parin DM,Bray F,Ferlay J,et al.estimating the world cancer burden Globocan 2000. Int J Cancer,2001,94:153-156. 3 Arbyn M,Castellsague X,de Sanjose S,et al.Worldwide burden of cervical cancer in 2008. Ann Oncol,2011,22:2675-2686. 4 Walboomers JM,Jacobs MV,Manos MM,et al.Human Papillomavirus is a necessary cause of invasive cervical cancer worldwide.J Pathol,1999,189:12-19. 5 王玥元,石清芳,田芳.宫颈液基薄层细胞学筛查中非典型鳞状细胞研究进展国际病理科学与临床杂志,2013,33:365-368. 6 Katki HA,Schiffman M,Castle PE,et al.Five-year risks of CIN 3+ and cervical cancer for women with HPV testing of ASC-US PaP results.J Low Genit Tract Dis,2013,17:S36-42. 7 ASCUS-LSIL Traige Study (ALTS) Group.Results of a randomized trial on the management of cytology interpretations of atypical squamous cells of undetermined significance.Am J Obstet Gynecol,2003,188:1383-1392. 8 Renshaw AA,Deschenes M,Auger M.ASC/SIL Ratio for Cytotechnologists A Surrogate Marker of Screening Sensitivity.Am J Clin Pathol,2009,131:776-781. 9 Origoni M,Carminati G,Sideri M,et al.Low-grade Positivity of HPV viral load after atypical squamous cells of undetermined significance(ASC-US)cytology identifies women at low-risk for cervical intraepithelial neoplasia grade 2 and 3.Eur J Gynaecol Oncol,2011,33:261-264. 10 Waldstrom M,Ornskov D.Clinical Performance of a human Papillomavirus messenger RNA test(APtima HPV Assay)on residual material from archived 3-year-old PreservCytsamPles with low-grade squamous intraepithelial lesion.Arch Pathol Lab Med,2011,135:1052-1056. 11 Wright Jr TC,Massad LS,Dunton CJ,et al.2006 consensus guidelines for the management of women with abnormal cervical screening tests.J Lower Genital Tract Dis,2007,11:201-222. 12 Ikenberg H,Bergeron C,Schmidt D,et al.Screening for cervical cancer Precursors with P16/Ki-67 dual-stainedcytology:results of the PALMS study.Natl Cancer Inst,2013,105:1550-1557. 13 Kisser A,Zechmeister-Koss I.A systematic review of P16 /Ki-67 immuno-testing For triage of low grade cervical cytology.BJOG,2015,122:64-70. 14 王鹤.中国五个地区妇女HPV感染型别研究与中国生殖器疣低危HPV型别感染的meta分析.北京:中国协和医科大学,2008.