抽动障碍患者血清Sirt1和IL-8水平

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摘要目的测定抽动障碍患者血清Sirt1和细胞因子IL-8水平,探讨Sirt1在抽动障碍免疫调节中的作用。方法选取2017年8月—2018年1月就诊于哈尔滨医科大学附属第一医院儿科的抽动障碍患儿100例作为实验组,选择性别和年龄相匹配的健康儿童78例为对照组。分别采集空腹静脉血,分离血清,采用ELISA方法定量检测血清中的Sirt1和IL-8浓度。结果血清Sirt1浓度值抽动障碍组为(19.1±8.8)ng/ml,对照组为(23.3±9.9)ng/ml,抽动障碍组明显低于对照组,差异有统计学意义(P<0.05);血清IL-8浓度值抽动障碍组为(141.6±53.6)pg/ml,对照组为(156.95±61.1)pg/ml,两组比较,差异无统计学意义(P>0.05)。结论抽动障碍患者血清Sirt1浓度降低,Sirt1可能参与抽动障碍的发生。

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	刘海春
	徐向平

关键词 ：抽动障碍, Sirt1, 发病机制, 免疫

Abstract：Objective To detect serum Sirt1 and cytokine IL-8 concentration in patients with tic disorders, and to investigate the role of Sirt1 in immunomodulation of patients with tic disorders. Methods A total of 100 children with tic disorders were selected as the experimental group in the pediatric department of the First Affiliated Hospital of Harbin Medical University from August 2017 to January 2018, and 78 healthy children matched with gender and age were selected as the control group. The fasting venous blood was collected respectively, and serum was separated. The serum Sirt1 and cytokine IL-8 concentrations were detected using ELISA. Results The serum Sirt1 concentration was (19.1±8.8) ng/ml and (23.3±9.9) ng/ml in the tic disorders group and control group respectively, the difference was statistically significant (P<0.05). The serum IL-8 concentration of tic disorders group and normal control group was (141.6±53.6) pg/ml and (157.0±61.1) pg/ml respectively. There is no significant difference (P>0.05) for the serum IL-8 concentrations in the two groups. Conclusion The serum Sirt1 concentration in patients with tic disorders is low, and it may participate in the pathogenesis of tic disorders.

Key words： Tic disorder Sirt1 pathogenesis immunity

收稿日期: 2019-12-12

通讯作者: 徐向平(xxp56@hotmail.com)

引用本文:

刘海春, 徐向平. 抽动障碍患者血清Sirt1和IL-8水平[J]. 中国生育健康杂志, 2020, 31(5): 440-443.
LIU Haichun, XU Xiangping. Detection of serum Sirt1 and IL-8 in patients with tic disorder. Chinese Journal of Reproductive Health, 2020, 31(5): 440-443.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2020/V31/I5/440

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