1 Sexton S.Folic Acid Supplementation for the Prevention of Neural Tube Defects:Recommendation Statement.Am Fam Physician,2017,95:652A-652C. 2 Sheridan M,Jamieson A.Life-threatening folic acid deficiency:Diogenes syndrome in a young woman?.Am J Med,2015,128:e7-8. 3 Liang Y,Li Y,Li Z,et al.Mechanism of folate deficiency-induced apoptosis in mouse embryonic stem cells:Cell cycle arrest/apoptosis in G1/G0 mediated by microRNA-302a and tumor suppressor gene Lats2. Int J Biochem Cell Biol,2012,44:1750-1760. 4 Corona Velazquez AF,Jackson WT.So Many Roads:the Multifaceted Regulation of Autophagy Induction.Mol Cell Biol,2018,38:e00303-18. 5 Wang Y,Yang Y,Zuo R,et al.FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.Biochem Biophys Res Commun,2020,524:756-763. 6 成军,主编.现代细胞自噬分子生物学.北京:科学出版社,2011:10-15. 7 Kabeya Y,Mizushima N,Ueno T,et al.LC3,a mammalian homologue of yeast Apg8p,is localized in autophagosome membranes after processing.EMBO J,2000,19:5720-5728. 8 Zhou W,Wang J,Qi Q,et al.Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway.Cancer Med,2018,7:4729-4743. 9 Mammucari C,Schiaffino S,Sandri M.Downstream of Akt:FoxO3 and mTOR in the regulation of autophagy in skeletal muscle.Autophagy,2008,4:524-526. 10 Chang S,Jing J,Shangguan S,et al.The effect of folic acid deficiency on Mest/Peg1 in neural tube defects.Int J Neurosci,2020,4:1-12. 11 秦佳星,牛勃,王建华.自噬调节基因AMBRA1在神经管发育中的作用及机制研究进展.中国生育健康杂志,2019,30:386-388.