Abstract:Objective To analyze the neurodevelopmental prognosis and its relevant risk factors in Very Preterm Infants(VPI).Methods From January 2017 to September 2019, 85 cases of VPI discharged from the Department of Neonatology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, were followed up, and their neurodevelopmental prognosis was assessed through the Intelligent Developmental Test(CDCC) at corrected age of one year. According to the prognostic results, VPIs were divided into normal group(43 cases) and abnormal group(42 cases). The clinical related factors and family factors those may have impacts on neurobehavioral development were listed. Univariate and multivariate logistic regression models were used to analyze the prognosis of VPI neurodevelopment and the risk factors.Results The birth weight of VPI in the normal group was(1.6±0.2) kg, higher than that in the abnormal group(1.4±0.3) kg. The hospital stay of VPI in the normal group was(40.8±9.2) d, lower than that in the abnormal group(45.7±9.9) d; The incidence of intracranial hemorrhage in the normal group was 11.6%, lower than that in the abnormal group(33.3%). The incidence of extremely low birth weight(ELBW) in the normal group was 14.0%, lower than that in the abnormal group(33.3%). The early education attendance and maternal education level in the normal group were significantly higher than those in the abnormal group, the VPI parents in the normal group paid more attention to early education than those in the abnormal group, and the VPI parents′ active intervention rate in the normal group was 41.9%, significantly higher than that in the abnormal group 14.3%. The aforementioned differences were all statistically significant. Logistic regression analysis showed that the low maternal education level, ELBW, intracranial hemorrhage were independent risk factors for the prognosis of VPI neurodevelopment, while parental attention to early education and active intervention were protective factors.Conclusion Parents′ education level, birth weight, intracranial hemorrhage, and parents′ attention to early education and intervention enthusiasm are closely related to the prognosis of VPI neurodevelopment.
胡晓琳, 史欢, 刘晶, 孟玉石, 罗小平, 陈玲. 极早早产儿神经发育预后随访结果及影响因素分析[J]. 中国生育健康杂志, 2021, 32(4): 319-323.
Hu Xiaolin, Shi Huan, Liu Jing, Meng Yushi, Luo Xiaoping, Chen Ling. Follow-up results and influencing factors of neurodevelopmental prognosis in very preterm infants(VPI). Chinese Journal of Reproductive Health, 2021, 32(4): 319-323.
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