Abstract：Objective To investigate the effects of fertility index and T lymphocyte subsets on the prognosis of patients with endometriosis combined infertility after laparoscopic surgery. Methods 168 patients with endometriosis combined infertility who underwent laparoscopy in our hospital from January 2013 to September 2015 were selected as the study group, in the same period, another 112 healthy married women who took part in physical examination in our hospital were selected as the control group, Endometriosis Fertility Index (EFI) score was applied to all patients, 5ml of cubital venous blood was taken from patients and normal women before operation, 1st day after operation and 7th day after operation, respectively, T cell subsets were analyzed by indirect immunofluorescence assay (IFA), the numbers of CD3+, CD4+ and CD8+, positive cells were counted, the CD4+/CD8+ was calculated. Results Within 3 years after laparoscopic surgery, the pregnancy rate of patients with endometriosis combined infertility was 53.6%, the preoperative CD3+, CD4+, CD4+/CD8+ ratio of the observation group were lower than those of the control group (P<0.05), and CD8+ was higher than that of the control group (P<0.05); One day after laparoscopic surgery CD3+, CD4+, CD4+/CD8+ ratio decreased (P<0.05), CD8+ increased (P<0.05); The CD3+, CD4+, CD4+/CD8+ ratio increased 7 days after operation (P>0.05), and CD8+ decreased (P<0.05); CD8+ was lower in patients with pregnancy failure before laparoscopic surgery, 1 day after operation and 7 days after operation (P<0.05); Logistic regression analysis showed that CD4+ and CD4+/CD8+ were independent risk factors for poor pregnancy outcome. Conclusion The fertility index and T lymphocyte subsets of endometriosis are related to the postoperative pregnancy status of patients with endometriosis complicated with infertility, which may be used as a reference index for prognosis evaluation of endometriosis complicated with infertility.
李红. 生育力指数及T淋巴细胞亚群对子宫内膜异位症合并不孕症腹腔镜术后患者预后的影响[J]. 中国生育健康杂志, 2021, 32(3): 238-242.
LI Hong. The Effects of Fertility Index and T Lymphocyte Subsets on Prognosis of Patients with Endometriosis Combined Infertility after Laparoscopic Surgery. Chinese Journal of Reproductive Health, 2021, 32(3): 238-242.
