1 Yildiz BO,Bozdag G,Yapici Z,et al.Prevalence,phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria.Hum Reprod,2012,27:3067-73. 2 Huang X,Liu C,Hao C,et al.Identification of altered microRNAs and mRNAs in the cumulus cells of PCOS patients:miRNA-509-3p promotes oestradiol secretion by targeting MAP3K8. Reproduction,2016,151:643-655. 3 Cai G,Ma X,Chen B,et al.MicroRNA-145 negatively regulates cell proliferation through targeting IRS1 in isolated ovarian granulosa cells from patients with polycystic ovary syndrome.Reprod Sci,2017,24:902-910. 4 Cha W,Fan R,Miao Y,et al.MicroRNAs as novel endogenous targets for regulation and therapeutic treatments.Medchemcomm,2017,9:396-408. 5 Song DK,Sung YA,Lee H.The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome.PLoS One,2016,27:e0163756. 6 Eisenberg I,Nahmias N,Novoselsky Persky M,et al.Elevated circulating micro-ribonucleic acid (miRNA)-200b and miRNA-429 levels in anovulatory women.Fertil Steril,2017,107:269-275. 7 Arancio W,Calogero Amato M,Magliozzo M,et al.Serum miRNAs in women affected by hyperandrogenic polycystic ovary syndrome:the potential role of miR-155 as a biomarker for monitoring the estroprogestinic treatment.Gynecol Endocrinol,2018,34:704-708. 8 Wang M,Liu M,Sun J,et al.MicroRNA-27a-3p affects estradiol and androgen imbalance by targeting Creb1 in the granulosa cells in mouse polycytic ovary syndrome model.Reprod Biol,2017,17:295-304. 9 Xiong W,Lin Y,Xu L,et al.Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS):the effects of body mass index and sex hormones in an Eastern Han Chinese population.J Ovarian Res,2017,10:10. 10 Long W,Zhao C,Ji C,et al.Characterization of serum microRNAs profile of PCOS and identification of novel non-invasive biomarkers.Cell Physiol Biochem,2014,33:1304-1315. 11 Ortega FJ,Mercader JM,Moreno-Navarrete JM,et al.Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization.Diabetes Care,2014,37:1375-1383. 12 Xue Y,Lv J,Xu P,et al.Identification of microRNAs and genes associated with hyperandrogenism in the follicular fluid of women with polycystic ovary syndrome.J Cell Biochem,2018,119:3913-3921. 13 Flammer J,Konieczka K.Retinal venous pressure:the role of endothelin.EPMA,2015,26:6-21. 14 Wang S,Guo X,Long CL,et al.SUR2B/Kir6.1 channel openers correct endothelial dysfunction in chronic heart failure via the miR-1-3p/ET-1 pathway.Biomed Pharmacother,2019,110:431-439. 15 Nguyen HL,Ruhoff AM,Fath T,et al.Hypoxic postconditioning enhances functional recovery following endothelin-1 induced middle cerebral artery occlusion in conscious rats.Exp Neurol,2018,306:177-189. 16 Rashad NM,Ateya MA,Saraya YS,et al.Association of miRNA-320 expression level and its target gene endothelin-1 with the susceptibility and clinical features of polycystic ovary syndrome.J Ovarian Res,2019,12:39. 17 Santonocito M,Vento M,Guglielmino MR,et al.Molecular characterization of exosomes and their microRNA cargo in human follicular fluid:bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation.Fertil Steril,2014,102:1751-1761. 18 Hossain MM,Cao M,Wang Q,et al.Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model.J Ovarian Res,2013,6:36. 19 Sang Q,Yao Z,Wang H,et al.Identification of microRNAs in human follicular fluid:characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo.J Clin Endocrinol Metab,2013,98:3068-3079. 20 Roth LW,McCallie B,Alvero R,et al.Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome.J Assist Reprod Genet,2014,31:355-362. 21 Artimani T,Saidijam M,Aflatoonian R,et al.Estrogen and progesterone receptor subtype expression in granulosa cells from women with polycystic ovary syndrome.Gynecol Endocrinol,2015,31:379-383. 22 Maalouf SW,Liu WS,Pate JL.MicroRNA in ovarian function.Cell Tissue Res,2016,363:7-18. 23 Jiang YC,Ma JX.The role of MiR-324-3p in polycystic ovary syndrome (PCOS) via targeting WNT2B.Eur Rev Med Pharmacol Sci,2018,22:3286-3293. 24 Hou Y,Wang Y,Xu S,et al.Bioinformatics identification of microRNAs involved in polycystic ovary syndrome based on microarray data.Mol Med Rep,2019,20:281-291. 25 He T,Sun Y,Zhang Y,et al.MicroRNA-200b and microRNA-200c are up-regulated in PCOS granulosa cell and inhibit KGN cell proliferation via targeting PTEN.Reprod Biol Endocrinol,2019,17:68. 26 Li D,Xu D,Xu Y,et al.MicroRNA-141-3p targets DAPK1 and inhibits apoptosis in rat ovarian granulosa cells.Cell Biochem Funct,2017,35:197-201. 27 Zhang Y,Wang J,Wu D,et al.IL-21-secreting hUCMSCs combined with miR-200c inhibit tumor growth and metastasis via repression of Wnt/β-catenin signaling and epithelial-mesenchymal transition in epithelial ovarian cancer.Onco Targets Ther,2018,10:2037-2050. 28 Li T,Mo H,Chen W,et al.Role of the PI3K-Akt signaling pathway in the pathogenesis of polycystic ovary syndrome.Reprod Sci,2017,24:646-655. 29 Díaz M,Bassols J,López-Bermejo A,et al.Low Circulating Levels of miR-451a in girls with polycystic ovary syndrome:different effects of randomized treatments.J Clin Endocrinol Metab,2020,105:204. 30 Wang G,Gu Y,Xu N,et al.Decreased expression of miR-150,miR146a and miR424 in type 1 diabetic patients:Association with ongoing islet autoimmunity.Biochem Biophys Res Commun,2018,498:382-387. 31 Gambineri A,Patton L,Altieri P,et al.Polycystic ovary syndrome is a risk factor for type 2 diabetes:results from a long-term prospective study.Diabetes,2012,61:2369-2374. 32 Dumas ME,Emanueli C.Circulating micrornas to predict the risk for metabolic diseases in the general population?.Diabetes,2017,66:565-567. 33 Chen YH,Heneidi S,Lee JM,et al.miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance.Diabetes,2013,62:2278-2286. 34 Wu HL,Heneidi S,Chuang TY,et al.The expression of the miR-25/93/106b family of micro-RNAs in the adipose tissue of women with polycystic ovary syndrome.J Clin Endocrinol Metab,2014,99:2754-2761. 35 Qin L,Chen J,Tang L,et al.Significant role of dicer and miR-223 in adipose tissue of polycystic ovary syndrome patients.Biomed Res Int,2019,11:9193236.