脂肪因子Omentin-1与妊娠期糖尿病的研究进展

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摘要妊娠期糖尿病(GDM)占妊娠人群的5%~20%,是最常见的妊娠相关疾病之一,患病率呈逐年上升趋势。因此,如何寻找GDM孕早期预测指标,提高GDM的筛查效率,预防和降低GDM的发生显得尤为重要。目前,GDM的发病机制尚未明确,据报道其与2型糖尿病(T2DM)较为相似,胰岛素抵抗增加是主要机制之一。越来越多的研究表明,以脂肪因子异常产生为特征的脂肪组织功能障碍是与IR和GDM相关的重要因素,其中内脏脂肪特异性脂肪因子(Omentin-1)是目前已知与IR相关的主要因子之一。研究显示,血循环中Omentin-1水平随着内脏肥胖的增加而降低,内脏脂肪中Omentin-1基因表达与其血浆水平呈正相关,内脏脂肪深度与IR相关,鉴于肥胖与GDM及Omentin-1的相关性,孕早期可以通过测量VAT联合血循环中Omentin-1水平来预测GDM的发生。本文主要通过回顾Omentin-1与GDM的相关研究来探讨Omentin-1在GDM发生、发展中的重要作用。

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	边秀平
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关键词 ：妊娠期糖尿病(GDM), 胰岛素抵抗(IR), 内脏脂肪深度(VAT), 预测

收稿日期: 2018-12-16

通讯作者: 孙敬霞(sjxsw2013@163.com)

引用本文:

边秀平, 吴艳莉, 李茹, 孙敬霞. 脂肪因子Omentin-1与妊娠期糖尿病的研究进展[J]. 中国生育健康杂志, 2021, 32(6): 590-592.

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http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2021/V32/I6/590

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