Abstract:Objective To explore the cumulative live birth rate of per oocytes retrieved cycle in patients with Endometriosis-infertility treated by In-vitro fertilization(IVF).Methods To retrospectively analyze the clinical data of 201 infertile couples who received IVF treatment for endometriosis as the main indication of infertility in the Department of Reproductive Medicine of our hospital from Jan, 2014 to Sep,2020. The participants were grouped in three ways:(1) groups by female age:≤35 years old, 35<-<40 years old, ≥40 years old; (2) groups by retrieved oocytes number:1-3, 4-5, 6-10, 11-15, ≥16; (3) groups by the history of laparoscopic/abdominal surgery:oophorocystectomy group, pelvic surgery without oophorocystectomy group, and no surgery group. The cumulative clinical pregnancy rate, cumulative miscarriage rate and cumulative live birth rate were compared among the groups.Results Among the 291 oocytes retrieved cycles, 16 cycles (5.5%) did not obtain oocytes, 47 cycles (16.2%) did not obtain available embryos. The cumulative clinical pregnancy rate, cumulative live birth rate, and cumulative miscarriage rate were 51.2%, 42.6% and 22.1%, respectively. The results by female age showed that women aged ≥40 years had significantly lower clinical pregnancy rate (12.5%) than women aged ≤35 years (58.0%) and women aged 35<-<40 years (62.0%). With increasing age, the cumulative miscarriage rate gradually increased (12.5%, 45.2%, 83.3%), and cumulative live birth rate gradually decreased (53.4%, 40.0%, 2.1%). The results by retrieved oocytes number showed that as the retrieved oocytes number increasing (1-3, 4-5, 6-10, 11-15, ≥16),the cumulative pregnancy rate (14.1%, 61.0%, 68.8%, 78.7%, 96.8%)and the cumulative live birth rate (8.7%, 53.7%, 60.9%, 63.8%, 80.7%) gradually increased. Results by the history of laparoscopic/abdominal surgery showed that patients with oophorocystectomy had lower cumulative clinical pregnancy rate and live birth rate than those without oophorocystectomy but received surgery treatment previously (43.6% vs 62.1%,36.1% vs 57.6%). When the number of oocytes retrieved was ≤3, the cumulative live birth rate was 10.6% in women aged ≤35 years and 0 in women aged >35 years for patients who had oophorocystectomy history.Conclusion The cumulative live birth rate of patients with endometriosis receiving IVF treatment might be correlated with the age of the woman and the number of oocytes retrieved. The low ovarian response caused by oophorocystectomy might be associated with adverse effect of IVF.
倪运萍, 陆杉, 徐珉, 王爱爱, 刘娟, 邓雪梅. 子宫内膜异位症患者行体外受精治疗单个取卵周期累积活产率分析[J]. 中国生育健康杂志, 2022, 33(3): 235-241.
NI Yunping, LU Shan, XU Min, WANG Aiai, LIU Juan, DENG Xuemei. Cumulative live birth rateof per oocyte retrieved cycle in Women with Endometriosis treated by In-vitro fertilization. Chinese Journal of Reproductive Health, 2022, 33(3): 235-241.
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