1 李永鹏.胎儿心脏发育与孕周关系曲线构建.安徽 合肥:安徽医科大学,2019. 2 Fouquet G,Coman T,Hermine O,et al.Serotonin,hematopoiesis and stem cells.Pharmacol Res,2019,140:67-74. 3 Tierney AJ.Feeding,hunger,satiety and serotonin in invertebrates.Proc Biol Sci,2020,287:20201386. 4 Cui S,Park H,Park H,et al.The Role of Serotonin in Ventricular Repolarization in Pregnant Mice.Yonsei Med J,2018,59:279-286. 5 王卫平,孙锟,常立文.儿科学.第9版.北京:人民卫生出版社,2018:264-266. 6 Laurent L,Huang C,Ernest SR, et al.In utero exposure to venlafaxine,a serotonin-norepinephrine reuptake inhibitor,increases cardiac anomalies and alters placental and heart serotonin signaling in the rat.Birth Defects Res A Clin Mol Teratol,2016,106:1044-1055. 7 Kliman HJ,Quaratella SB,Setaro AC,et al.Pathway of Maternal Serotonin to the Human Embryo and Fetus.Endocrinology,2018,159:1609-1629. 8 Laurent L,Deroy K,St-Pierre J,et al.Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase.Biochimie,2017,140:159-165. 9 李继承,曾园山.组织学与胚胎学.第 9版.北京:人民卫生出版社,2018:206-210. 10 Ori M,De Lucchini S,Marras G,et al.Unraveling new roles for serotonin receptor 2B in development:key findings from Xenopus.Int J Dev Biol,2013,57:707-714. 11 Ayme-Dietrich E,Lawson R,Da-Silva S,et al.Serotonin contribution to cardiac valve degeneration:new insights for novel therapies?.Pharmacol Res,2019,140:33-42. 12 Fitzgerald LW,Burn TC,Brown BS,et al.Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.Mol Pharmacol,2000,57:75-81. 13 Rajamannan NM,Caplice N,Anthikad F,et al.Cell proliferation in carcinoid valve disease:a mechanism for serotonin effects.J Heart Valve Dis,2001,10:827-831. 14 Hutcheson JD,Setola V,Roth BL,et al.Serotonin receptors and heart valve disease--it was meant 2B.Pharmacol Ther,2011,132:146-157. 15 Jian B,Xu J,Connolly J,et al.Serotonin mechanisms in heart valve disease I:serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells.Am J Pathol,2002,161:2111-2121. 16 Hutcheson JD,Ryzhova LM,Setola V,et al.5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation.J Mol Cell Cardiol,2012,53:707-714. 17 Sauls K,de Vlaming A,Harris BS,et al.Developmental basis for filamin-A-associated myxomatous mitral valve disease.Cardiovasc Res,2012,96:109-119. 18 Sadler TW.Selective serotonin reuptake inhibitors (SSRIs) and heart defects:Potential mechanisms for the observed associations.Reprod Toxicol,2011,32:484-489. 19 Maslen CL.Recent Advances in Placenta-Heart Interactions.Front Physiol,2018,9:735. 20 Rosenfeld CS.Placental serotonin signaling,pregnancy outcomes,and regulation of fetal brain development†.Biol Reprod,2020,102:532-538. 21 Huhta J,Linask KK.Environmental origins of congenital heart disease:the heart-placenta connection.Semin Fetal Neonatal Med,2013,18:245-250. 22 Adams RH,Porras A,Alonso G,et al.Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development.Mol Cell,2000,6:109-116. 23 Hemberger M,Cross JC.Genes governing placental development.Trends Endocrinol Metab,2001,12:162-168. 24 Gessert S,Kühl M.The multiple phases and faces of wnt signaling during cardiac differentiation and development.Circ Res,2010,107:186-199. 25 Fukumoto T,Kema IP,Levin M.Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos.Curr Biol,2005,15:794-803. 26 Beyer T,Danilchik M,Thumberger T,et al.Serotonin signaling is required for Wnt-dependent GRP specification and leftward flow in Xenopus.Curr Biol,2012,22:33-39. 27 Linask KK.The heart-placenta axis in the first month of pregnancy:induction and prevention of cardiovascular birth defects.J Pregnancy,2013,2013:320413.