基于线粒体功能障碍的多囊卵巢综合征研究进展

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摘要多囊卵巢综合征(PCOS)是妇科常见的一种内分泌代谢紊乱性和生殖障碍性疾病,目前其具体发病机制尚不明确。既往研究表明,线粒体形态损伤、功能障碍和mtDNA突变在PCOS发生发展过程中有着重要意义,它们既导致了PCOS及其远期并发症的发生,也是缓解PCOS临床症状的重要治疗靶点。二甲双胍、褪黑素、MitoQ10和维生素D3等多种治疗方法能够通过恢复线粒体形态和呼吸链功能,促进线粒体生物发生过程,改善PCOS临床症状。本文围绕线粒体蛋白质功能障碍和基因改变的研究进展以及基于线粒体功能改善的PCOS治疗进展进行阐述。

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	杨乔瑞
	潘紫萌
	孙畅
	孙淼
	匡洪影

关键词 ：线粒体, 基因突变, 功能障碍, 多囊卵巢综合征, 研究进展

收稿日期: 2021-05-10

ZTFLH:

R71

基金资助:国家自然科学基金青年科学基金项目(81804138);黑龙江省博士后科研启动金(LBHQ18119)

引用本文:

杨乔瑞, 潘紫萌, 孙畅, 孙淼, 匡洪影. 基于线粒体功能障碍的多囊卵巢综合征研究进展[J]. 中国生育健康杂志, 2022, 33(6): 593-596.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2022/V33/I6/593

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