Abstract：Objective To investigate the neonatal outcomes after short time insemination combined with early rescue intracytoplasmic sperm injection (early-RICSI).Methods We retrospectively analyzed the neonatal outcomes of live births born by patients who underwent in vitro fertilization (IVF) or early-RICSI treatment between January 1, 2015 and December 31, 2020 in Tongji Hospital. The interested outcomes included sex ratio, gestational age, birthweight, rate of preterm birth, very preterm birth, low birthweight, very low birthweight and macrosomia. The patients were divided into IVF group or Early-RICSI group, according to the types of fertilization. Finally, 4927 singletons and 2477 twins were included in IVF group, and 369 singletons and 161 twins were included in Early-RICSI group.Results Among singleton live births, no differences were observed between groups in cesarean rate, sex ratio, gestational age, rate of preterm birth and very preterm birth, birthweight, rate of low birthweight, very low birthweight and macrosomia. However, among twin live births, the mean birthweight in IVF group was significantly lower than early-RICSI group (adjusted mean difference and 95% confidence interval:52.3(13.8,90.9)g,P=0.008), while the cesarean rate, sex ratio, gestational age, rate of preterm birth and very preterm birth, rate of low birthweight, very low birthweight and macrosomia were comparable between groups after adjustment for confounding factors.Conclusions hort time insemination combined with early-RICSI treatment did not add extra risks to the neonatal outcomes.
贺慧, 黄博, 吴黎, 任新玲, 靳镭, 江亚萍. 短时受精结合早期补救单精子卵胞浆注射技术的新生儿结局[J]. 中国生育健康杂志, 2023, 34(2): 120-123.
HE Hui, HUANG Bo, WU Li, REN Xinling, JIN Lei, JIANG Yaping. Neonatal outcomes after short time insemination combined with early rescue intracytoplasmic sperm injection. Chinese Journal of Reproductive Health, 2023, 34(2): 120-123.
1 Bhattacharya S,Hamilton MP,Shaaban M,et al. Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility:a randomised controlled trial.Lancet,2001,357:2075-2079. 2 Liu DY,Baker HW.Defective sperm-zona pellucida interaction:a major cause of failure of fertilization in clinical in-vitro fertilization.Hum Reprod,2000,15:702-708. 3 Huang B,Qian K,Li Z,et al.Neonatal outcomes after early rescue intracytoplasmic sperm injection:an analysis of a 5-year period.Fertil Steril,2015,103:1432-1437.e1. 4 聂玉林,赵魁,周静,等.短时授精联合早期补救ICSI对受精失败高危人群的应用结局.当代医学,2020,26:115-118. 5 Chen C,Kattera S.Kattera.Rescue ICSI of oocytes that failed to extrude the second polar body 6 h post-insemination in conventional IVF.Hum Reprod,2003,18:2118-2121. 6 林碎玲,李雪梅,刘红,等.短时受精失败后早期补救卵胞浆内单精子注射的最佳窗口期.中国妇幼保健,2017,32:3273-3276. 7 Nagy ZP,Joris H,Liu J,et al.Intracytoplasmic single sperm injection of 1-day-old unfertilized human oocytes.Hum Reprod,1993,8:2180-2184. 8 Tesarik J.Associate editor's comment on 'Rescue ICSI of oocytes that failed to extrude the second polar body 6 h post-insemination in conventional IVF' by Chen and Kattera.Rescue ICSI revisited.Hum Reprod,2003,18:2122-2123. 9 Xiong F,Sun Q,Li G,et al.Perinatal and neonatal outcomes of pregnancies after early rescue intracytoplasmic sperm injection in women with primary infertility compared with conventional intracytoplasmic sperm injection:a retrospective 6-year study.BMC Pregnancy Childbirth,2020,20:460. 10 吴丽敏,鲍蔓蔓,童先宏,等.早期补救卵胞浆内单精子注射妊娠结局及新生儿出生结局评估.实用妇产科杂志,2018,34:782-786. 11 王紫娟,游敏,张红梅,等.辅助生殖技术中短时受精失败结合早期补救ICSI与常规ICSI的临床结局分析.山西医科大学学报,2019,50:79-85.
