Abstract:Objective To investigate the significance of HPV extended typing except HPV16/18 in high-grade intraepithelial lesions of HSIL and cervical cancer screening. Methods A total of 1200 women with HPV infection who attended Lingang campus of Shanghai sixth people's hospital from Jan. 2018 to Dec. 2020 were selected for retrospective analysis. At the meantime, a total of 868 women including some of them and other women who underwent colposcope and histopathology examination were divided into two groups according to the occurrence of HSIL or cervical cancer. The results of HPV infection in different age groups and subtypes were statistically analyzed. The efficacy of TCT, high-risk HPV subtypes and their combinations in predicting HSIL and cervical cancer was calculated. Results 1.The top three subtypes were HPV52, HPV16 and HPV58, respectively, among the 1200 women infected with HPV. And the multiple infection rate was higher in women over 60 years old(χ2=5.56,P=0.022). 2. HPV16, HPV31 and HPV33 were associated with the occurrence of HSIL and cervical cancer, and Logistic regression analysis showed that the infection of these three subtypes were independent risk factors. 3. The highest rates of HSIL and cervical cancer were found in patients aged 60 years and older(χ2=8.322,P=0.004). Conclusion 1. In addition to HPV16/18 subtype, expanded typing of other high-risk subtypes such as HPV31, HPV33, HPV52 and HPV58 in this region is helpful to avoid missed diagnosis of HSIL and cervical cancer; 2. There is no significant difference in the susceptibility of women of all ages to most high-risk subtypes of HPV, so cervical cancer screening and follow-up for women over 60 years old in this region should be strengthened, and individualized screening and follow-up programs should be advocated.
肖静, 李莉, 邹锋, 陈宇. HPV拓展分型检测在宫颈癌筛查中的临床意义[J]. 中国生育健康杂志, 2023, 34(3): 243-247.
XIAO Jing, LI Li, ZOU Feng, CHEN Yu. Study on HPV extended typing test in cervical cancer screening. Chinese Journal of Reproductive Health, 2023, 34(3): 243-247.
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