Objective To investigate the effect of exogenous nucleotides on fertility in parents rats and the indexes of physiological and neural development in newborn rots over the three - reproductive exper-iment, and evaluate the safety on development. Methods Weanling rats (F0) were fed to exogenous nucleotides at the dose of 0, 0. 01%, 0. 04 %, 0.16 %,0.64 %, 1.28 % for 90 days and then male and female rats mated for 1 : 1 pattern. The offspring of F0 was F1. F1 rats were fed to exogenous nucleotides for 90 days after they were weaned. And then these rants go on to the second reproductive experiment. Repeat the progress above until F3 rats were born. In the whole period, we observed the gestational, partal, lacta-tional period in parent rats and the lactatioual period and the indexes of physiological and neural development in newborn rats. Results No abnormal situation was found among the gestatioual, partal, lactatioual pe-riod in parent rats and the lactational period and the indexes of physiological and neural development in new-born rats. Conclusion At the dose of the experiment, supplementing exogenous nucleotides was safe to reproductive function and embryonic, fetal, lactational period in multi -generation rats.
