DNA甲基化改变与神经管缺陷关系研究进展

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摘要神经管缺陷是一类严重的先天缺陷性疾病。有研究显示,神经管缺陷的发生可能与DNA甲基化异常有关。本文对发育期胚胎神经管形成相关基因甲基化及神经管缺陷相关的DNA甲基化异常研究进行综述,探讨一碳单位代谢因子,环境污染物及高糖三类外界因素与DNA甲基化在神经管缺陷发生中的可能作用。同时,对目前研究中存在的问题及今后的研究方向进行简要论述。

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	作者相关文章
	黄芸
	林珊珊
	任爱国

关键词 ：神经管缺陷, DNA甲基化, 环境污染物

收稿日期: 2017-03-20

基金资助:国家重点研发计划(2016YFC1000501)

通讯作者: 任爱国(renag@bjmu.edu.cn)

引用本文:

黄芸, 林珊珊, 任爱国. DNA甲基化改变与神经管缺陷关系研究进展[J]. 中国生育健康杂志, 2018, 29(2): 190-193.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2018/V29/I2/190

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