Serum iron levels in preeclampsia in third trimester of pregnancy:A meta-analysis
CHEN Sen, LI Nan, YANG Na, OUYANG Hanqiang, LIU Yingjuan, YE Rongwei
Department of Epidemiology and Biostatistics, School of Public Health; Institute of Reproductive and Child Health; Ministry of Health Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China
Abstract：Objective To investigate the association between serum iron concentrations in the third trimester of pregnancy and the occurrence of preeclampsia (PE) by a Meta-analysis. Methods Databases including PubMed, Web of Science, CNKI, WANFANG, and VIP were searched to identify case-control studies on iron levels in the third trimester of pregnancy and PE as of March 2014. Selected publications were included in the Meta-analysis. Results Twenty-one case-control studies were included. The results showed that serum iron level in preeclampsia was higher than that of control group, but without a difference being statistically significant [SMD=0.39,95% CI:-0.34-1.12, P=0.29]. Compared with control group, serum iron level in mild and severe PE were both higher, with both differences being significant [SMD=1.84, 95% CI:0.65-3.03, P<0.05; SMD=2.82, 95% CI:1.52-4.13, P<0.0001, respectively]. Conclusion Serum iron levels in the third trimester of pregnancy were associated with occurrence of PE.
陈森, 李楠, 杨娜, 欧阳汉强, 刘莹娟, 叶荣伟. 孕晚期血清铁水平与子痫前期关系的Meta分析[J]. 中国生育健康杂志, 2015, 26(1): 7-10.
CHEN Sen, LI Nan, YANG Na, OUYANG Hanqiang, LIU Yingjuan, YE Rongwei. Serum iron levels in preeclampsia in third trimester of pregnancy:A meta-analysis. Chinese Journal of Reproductive Health, 2015, 26(1): 7-10.
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