Abstract：Objective The experiment aimed to study the effect of genetically modified maize Bt-799 on Wistar rats' physical, physiological, and neural reflex development. Methods Wistar rats were divided into several groups. Different doses of genetically modified maize were given to the rats until 12 weeks old; then the rates mated. After birth, the body weight of several time points were recorded, and the indicators of physiological and neural reflex development of the offspring were detected. Two successive generations were conducted. Results F1 offspring grew steadily after birth, and the body weight of different time points had no statistically significant difference. As time went on, the body weight of the newborn rats of F2 gradually increased. On the fourth, seventh and fourteenth day after birth, the body weight of TH group and N group were higher than BC group. And the body weight of TH group, GTH group, and N group were also higher than BC group when they were 21 days old. The differences were both statistically significant. Physiological development, including separation of auricles, eruption of incisors, opening eyes, descent of testicular, and opening of vagina, in F1 offspring had no significant difference among the groups. While the time of opening eyes was earlier in F2 offspring consuming TH diet and N diet compared with control diet. However, there was no significant difference between F2 offspring consuming TH diet and those consuming N diet. The neural reflex development had no statistically significant difference in F1 and F2 offspring consuming transgenic maize diets compared with non-transgenic maize diet and control diet. Not only the physiological development but also the neural reflex development was advanced in F2 offspring compared with F1 offspring. Conclusion The study showed that genetically modified maize Bt-799 has toxic effects on the development of Wistar rats offspring.
尚俊丽, 郭倩颖, 朱晗, 何丽霞, 朱凌燕, 李勇. 转基因玉米Bt-799对Wistar大鼠仔代发育的影响[J]. 中国生育健康杂志, 2015, 26(1): 28-32.
SHANGJunli, GUO Qianying, ZHU Han, HE Lixia, ZHU Lingyan, LI Yong. Experimental study on effects of genetically modified maize Bt-799 on development of Wistar rats offspring. Chinese Journal of Reproductive Health, 2015, 26(1): 28-32.
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