Abstract:Objective This study examined the impact of childhood neonatal isolation (NI) and neonatal tactile stimulation (NTS) on social behavior and oxytocin (OXT)/vasopressin (AVP) systems in hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON) of rats in adulthood.Methods 78 rats were randomly divided into standard facility rearing (SFR), NI and NTS groups. After receiving intervention according to neonatal period, social interaction test and immunohistochemical test were carried out in their adulthood.Results Childhood NI had negative effects on social interaction behavior in their adulthood, and the behavioral change was more obvious in female rats interacting to both sexes (female to male or female), and in both sexes interacting between the same sex (male to male and female to female). The results of immunohistochemical staining showed that in NI group, female rats had significant reductions in the number of OXT-immunopositive neurons in magnocellular region of PVN and in the AVP-immunopositive neurons in both magnocellular and parvocellular regions of PVN. The change in behavior and molecule was partially reversed in NTS group. Correlation analysis showed that in female rats, the numbers of OXT- and AVP-immunopositive neurons in PVN were positively correlated to the social interaction ability.Conclusion NI and NTS may have long-term impact on social interaction behavior in female rats through the OXT/AVP system in the PVN areas, which are known to be involved in social behavior in mammals.
安勇博,梁文英*,李轶雯,刘璐,王冬青,戴笑颜,马驰,钱驿,马瑞,丁瞳,张嵘. 新生儿期母子隔离与抚触刺激对成年后大鼠社会交往行为的影响[J]. 中国生育健康杂志, 2017, 28(1): 23-30.
AN Yongbo, LIANG Wenying, LI Yiwen, LIU Lu, WANG Dongqing, DAI Xiaoyan, MA Chi, QIAN Yi, MA Rui, DING Tong, ZHANG Rong. Effects of neonatal isolation and neonatal tactile stimulation on social behavior of adult rats. Chinese Journal of Reproductive Health, 2017, 28(1): 23-30.
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